Synthesis and characterization of amino acid conjugates of oleanolic acid and their in vitro cytotoxic effect on HCC cell lines

Date
2014
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Source Title
Pakistan Journal of Pharmaceutical Sciences
Print ISSN
1011-601X
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Publisher
Pakistan Journal of Pharmaceutical Sciences
Volume
27
Issue
5
Pages
1491 - 1496
Language
English
Type
Article
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Abstract

Oleanolic acid (3β-hydroxy-olean-12-en-28-oic acid; OA-01), a pentacyclic triterpene, exhibit a wide range of pharmacological and biological activities. We have isolated oleanolic acid from methanolic extract of Periploca aphylla, collected from surroundings of Karachi in the month of February. Furthermore, four known and two new C-28 amino acid conjugates of oleanolic acid were prepared to explore potential of these compounds on HCCs and one breast cancer cell line. Cytotoxic effects revealed that as compare to parent compound (OA-01), two derivatives OA-04 (p<0.0001) and OA-06 (p<0.01) showed significantly increased/higher inhibition rates.

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Keywords
Oleanolic acid, Amino acid, HCC cell lines, Amides, Periploca aphylla, Cell survival, Liver cell carcinoma, Breast tumor, Liver tumor
Citation
Published Version (Please cite this version)