Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Date
2020
Editor(s)
Advisor
Supervisor
Co-Advisor
Co-Supervisor
Instructor
Source Title
Science
Print ISSN
0036-8075
Electronic ISSN
1095-9203
Publisher
American Association for the Advancement of Science
Volume
370
Issue
6515
Pages
1 - 16
Language
English
Type
Journal Title
Journal ISSN
Volume Title
Citation Stats
Attention Stats
Usage Stats
4
views
views
18
downloads
downloads
Series
Abstract
Clinical outcomes of human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus disease 2019 (COVID-19). Epidemiological studies have identified three risk factors for severe disease: being male, being elderly, and having other medical conditions. However, interindividual clinical variability remains huge in each demographic category. Discovering the root cause and detailed molecular, cellular, and tissue- and body-levelmechanismsunderlying life-threatening COVID-19 is of the utmost biological and medical importance.