Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

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Inborn_errors_of_type_I_IFN_immunity_in_patients_with_life_threatening_COVID-19.pdf (1.34 MB)

Date

2020

Authors

Zhang, Q.
Liu, Z.
Moncada-Velez, M.
Chen, J.
Ogishi, M.
Bigio, B.
Yang, R.
Arias, A. A.
Zhou, Q.
Han, J. E.

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Abstract

Clinical outcomes of human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus disease 2019 (COVID-19). Epidemiological studies have identified three risk factors for severe disease: being male, being elderly, and having other medical conditions. However, interindividual clinical variability remains huge in each demographic category. Discovering the root cause and detailed molecular, cellular, and tissue- and body-levelmechanismsunderlying life-threatening COVID-19 is of the utmost biological and medical importance.

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Science

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American Association for the Advancement of Science

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http://hdl.handle.net/11693/75852

Published Version (Please cite this version)

https://dx.doi.org/10.1126/science.abd4570

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Scholarly Publications - Molecular Biology and Genetics

Language

English

Type

Article