Microcantilever based disposable viscosity sensor for serum and blood plasma measurements

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dc.citation.epage232en_US
dc.citation.issueNumber3en_US
dc.citation.spage225en_US
dc.citation.volumeNumber63en_US
dc.contributor.authorCakmak O.en_US
dc.contributor.authorElbuken, C.en_US
dc.contributor.authorErmek, E.en_US
dc.contributor.authorMostafazadeh, A.en_US
dc.contributor.authorBaris I.en_US
dc.contributor.authorErdem Alaca, B.en_US
dc.contributor.authorKavakli I.H.en_US
dc.contributor.authorUrey H.en_US
dc.date.accessioned2016-02-08T09:35:01Z
dc.date.available2016-02-08T09:35:01Z
dc.date.issued2013en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractThis paper proposes a novel method for measuring blood plasma and serum viscosity with a microcantilever-based MEMS sensor. MEMS cantilevers are made of electroplated nickel and actuated remotely with magnetic field using an electro-coil. Real-time monitoring of cantilever resonant frequency is performed remotely using diffraction gratings fabricated at the tip of the dynamic cantilevers. Only few nanometer cantilever deflection is sufficient due to interferometric sensitivity of the readout. The resonant frequency of the cantilever is tracked with a phase lock loop (PLL) control circuit. The viscosities of liquid samples are obtained through the measurement of the cantilever's frequency change with respect to a reference measurement taken within a liquid of known viscosity. We performed measurements with glycerol solutions at different temperatures and validated the repeatability of the system by comparing with a reference commercial viscometer. Experimental results are compared with the theoretical predictions based on Sader's theory and agreed reasonably well. Afterwards viscosities of different Fetal Bovine Serum and Bovine Serum Albumin mixtures are measured both at 23. °C and 37. °C, body temperature. Finally the viscosities of human blood plasma samples taken from healthy donors are measured. The proposed method is capable of measuring viscosities from 0.86. cP to 3.02. cP, which covers human blood plasma viscosity range, with a resolution better than 0.04. cP. The sample volume requirement is less than 150. μl and can be reduced significantly with optimized cartridge design. Both the actuation and sensing are carried out remotely, which allows for disposable sensor cartridges. © 2013 .en_US
dc.identifier.doi10.1016/j.ymeth.2013.07.009en_US
dc.identifier.issn10462023
dc.identifier.urihttp://hdl.handle.net/11693/20776
dc.language.isoEnglishen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.ymeth.2013.07.009en_US
dc.source.titleMethodsen_US
dc.subjectBlooden_US
dc.subjectBlood Plasmaen_US
dc.subjectCantileveren_US
dc.subjectMagnetic actuationen_US
dc.subjectMEMSen_US
dc.subjectMicrocantileveren_US
dc.subjectSerumen_US
dc.subjectViscosityen_US
dc.subjectbovine serum albuminen_US
dc.subjectglycerolen_US
dc.subjectarticleen_US
dc.subjectblood samplingen_US
dc.subjectbody temperatureen_US
dc.subjectcontrolled studyen_US
dc.subjectdisposable equipmenten_US
dc.subjectdynamicsen_US
dc.subjecthumanen_US
dc.subjectmagnetic fielden_US
dc.subjectplasma viscosityen_US
dc.subjectpriority journalen_US
dc.subjectsensoren_US
dc.subjectviscometeren_US
dc.subjectviscometryen_US
dc.subjectBovinaeen_US
dc.subjectBlooden_US
dc.subjectBlood Plasmaen_US
dc.subjectCantileveren_US
dc.subjectMagnetic actuationen_US
dc.subjectMEMSen_US
dc.subjectMicrocantileveren_US
dc.subjectSerumen_US
dc.subjectViscosityen_US
dc.subjectAnimalsen_US
dc.subjectBiosensing Techniquesen_US
dc.subjectBlood Viscosityen_US
dc.subjectCattleen_US
dc.subjectHumansen_US
dc.subjectPlasmaen_US
dc.subjectSerumen_US
dc.titleMicrocantilever based disposable viscosity sensor for serum and blood plasma measurementsen_US
dc.typeArticleen_US

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Institute of Materials Science and Nanotechnology (UNAM)