Mitochondrial carrier homolog 1 (Mtch1) antibodies in neuro-Behçet's disease

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dc.citation.epage144en_US
dc.citation.issueNumber1-2en_US
dc.citation.spage139en_US
dc.citation.volumeNumber263en_US
dc.contributor.authorVural, B.en_US
dc.contributor.authorŞehitoğlu, E.en_US
dc.contributor.authorÇavuş, F.en_US
dc.contributor.authorYalçınkaya, N.en_US
dc.contributor.authorHaytural, H.en_US
dc.contributor.authorKüçükerden, M.en_US
dc.contributor.authorUlusoy, C.en_US
dc.contributor.authorUğurel, E.en_US
dc.contributor.authorTuran, S.en_US
dc.contributor.authorBulut, L.en_US
dc.contributor.authorTürkoğlu, R.en_US
dc.contributor.authorShugaiv, E.en_US
dc.contributor.authorKürtüncü, M.en_US
dc.contributor.authorAtakan, S.en_US
dc.contributor.authorGüre, A. O.en_US
dc.contributor.authorGül, A.en_US
dc.contributor.authorEraksoy, M.en_US
dc.contributor.authorDemir, G. A.en_US
dc.contributor.authorTüzün, E.en_US
dc.date.accessioned2016-02-08T09:34:43Z
dc.date.available2016-02-08T09:34:43Z
dc.date.issued2013en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractEfforts for the identification of diagnostic autoantibodies for neuro-Behcet's disease (NBD) have failed. Screening of NBD patients' sera with protein macroarray identified mitochondrial carrier homolog 1 (Mtch1), an apoptosis-related protein, as a potential autoantigen. ELISA studies showed serum Mtch1 antibodies in 68 of 144 BD patients with or without neurological involvement and in 4 of 168 controls corresponding to a sensitivity of 47.2% and specificity of 97.6%. Mtch1 antibody positive NBD patients had more attacks, increased disability and lower serum nucleosome levels. Mtch1 antibody might be involved in pathogenic mechanisms of NBD rather than being a coincidental byproduct of autoinflammation. © 2013 Elsevier B.V.en_US
dc.identifier.doi10.1016/j.jneuroim.2013.08.007en_US
dc.identifier.eissn1872-8421
dc.identifier.issn0165-5728
dc.identifier.urihttp://hdl.handle.net/11693/20761
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.jneuroim.2013.08.007en_US
dc.source.titleJournal of Neuroimmunologyen_US
dc.subjectBehçet's diseaseen_US
dc.subjectNeuro-Behçet's diseaseen_US
dc.subjectAnti-neuronal antibodyen_US
dc.subjectMitochondrial carrier homolog 1en_US
dc.subjectAntibodyen_US
dc.subjectAutoimmunityen_US
dc.titleMitochondrial carrier homolog 1 (Mtch1) antibodies in neuro-Behçet's diseaseen_US
dc.typeArticleen_US

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