Mitochondrial carrier homolog 1 (Mtch1) antibodies in neuro-Behçet's disease

Date
2013
Authors
Vural, B.
Şehitoğlu, E.
Çavuş, F.
Yalçınkaya, N.
Haytural, H.
Küçükerden, M.
Ulusoy, C.
Uğurel, E.
Turan, S.
Bulut, L.
Advisor
Supervisor
Co-Advisor
Co-Supervisor
Instructor
Source Title
Journal of Neuroimmunology
Print ISSN
0165-5728
Electronic ISSN
1872-8421
Publisher
Elsevier
Volume
263
Issue
1-2
Pages
139 - 144
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Series
Abstract

Efforts for the identification of diagnostic autoantibodies for neuro-Behcet's disease (NBD) have failed. Screening of NBD patients' sera with protein macroarray identified mitochondrial carrier homolog 1 (Mtch1), an apoptosis-related protein, as a potential autoantigen. ELISA studies showed serum Mtch1 antibodies in 68 of 144 BD patients with or without neurological involvement and in 4 of 168 controls corresponding to a sensitivity of 47.2% and specificity of 97.6%. Mtch1 antibody positive NBD patients had more attacks, increased disability and lower serum nucleosome levels. Mtch1 antibody might be involved in pathogenic mechanisms of NBD rather than being a coincidental byproduct of autoinflammation. © 2013 Elsevier B.V.

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Other identifiers
Book Title
Keywords
Behçet's disease, Neuro-Behçet's disease, Anti-neuronal antibody, Mitochondrial carrier homolog 1, Antibody, Autoimmunity
Citation
Published Version (Please cite this version)