Dual-stoichiometry copper sulphide nanoparticles by laser ablation in DMSO: synthesis and biomedical applications for enhanced photothermal therapy and photoacoustic imaging

buir.contributor.authorTaylan, Umut
buir.contributor.authorAkçimen, Samet
buir.contributor.authorEş, İsmail
buir.contributor.authorKüçük, Beyza Nur
buir.contributor.authorTekgül, Esra Kendir
buir.contributor.authorÇelebi, Çağatay
buir.contributor.authorKumru, Yasin
buir.contributor.authorKöymen, Hayrettin
buir.contributor.authorİnci, Fatih
buir.contributor.authorOrtaç, Bülend
buir.contributor.orcidTaylan, Umut|0000-0003-4548-9391
buir.contributor.orcidAkçimen, Samet|0000-0002-4633-0908
buir.contributor.orcidEş, İsmail|0000-0002-7369-1039
buir.contributor.orcidTekgül, Esra Kendir|0000-0002-6728-5640
buir.contributor.orcidKöymen, Hayrettin|0000-0002-9768-2110
buir.contributor.orcidİnci, Fatih|0000-0002-9918-5038
buir.contributor.orcidOrtaç, Bülend|0000-0002-1104-7459
dc.citation.epagee202400057-14
dc.citation.issueNumber8
dc.citation.spagee202400057-1
dc.citation.volumeNumber10
dc.contributor.authorTaylan, Umut
dc.contributor.authorAkçimen, Samet
dc.contributor.authorEş, İsmail
dc.contributor.authorKüçük, Beyza Nur
dc.contributor.authorTekgül, Esra Kendir
dc.contributor.authorÇelebi, Çağatay
dc.contributor.authorKumru, Yasin
dc.contributor.authorKöymen, Hayrettin
dc.contributor.authorİnci, Fatih
dc.contributor.authorOrtaç, Bülend
dc.date.accessioned2025-02-15T14:13:28Z
dc.date.available2025-02-15T14:13:28Z
dc.date.issued2024-05-13
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)
dc.departmentAcoustics and Underwater Technologies Research Center (BASTA)
dc.departmentDepartment of Electrical and Electronics Engineering
dc.description.abstractCopper sulphide nanoparticles are synthesized by laser ablation of a copper target in DMSO by a 527 nm nanosecond pulsed laser. These nanoparticles have double stoichiometry (CuS and $Cu_{1.8}S$) and crystalline structures, sizes under 30 nm, and they present substantial absorbance in the second near-infrared window and photoluminescence in the visible region. The nanoparticles are used as photothermal and photoacoustic agents at 1080 nm and 1064 nm, respectively. Utilizing as a photothermal agent, these nanoparticles rapidly exhibit local heating, photothermal stability, and a temperature change of 52.2 °C within 300 s at $1 mg mL^{−1}$ concentration and $3.23 W cm^{−2}$ laser intensity. On the other hand, while employed as a photoacoustic agent, they enhanced the contrast significantly and increased the brightness proportional to their concentrations when compared to ultrasound imaging. Additionally, the biocompatibility properties of these nanoparticles were tested with cancer cells, and they were subjected to laser ablation to assess their photothermal effects. In this article, we demonstrate that copper sulphide nanoparticles synthesized by pulsed laser ablation hold great promise for photothermal and photoacoustic applications, especially in biomedical applications.
dc.identifier.doi10.1002/cnma.202400057
dc.identifier.eissn2199-692X
dc.identifier.urihttps://hdl.handle.net/11693/116274
dc.language.isoEnglish
dc.publisherWiley-VCH Verlag GmbH & Co. KGaA
dc.relation.isversionofhttps://dx.doi.org/10.1002/cnma.202400057
dc.rightsCC BY-NC-ND 4.0 (Attribution-NonCommercial-NoDerivatives 4.0 International Deed)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.source.titleChemNanoMat
dc.subjectCopper sulphide nanoparticles
dc.subjectLaser ablation in liquid
dc.subjectPhotothermal
dc.subjectPhotoacoustic
dc.subjectCancer
dc.subjectCell viability
dc.titleDual-stoichiometry copper sulphide nanoparticles by laser ablation in DMSO: synthesis and biomedical applications for enhanced photothermal therapy and photoacoustic imaging
dc.typeArticle

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