Angiogenic heparin-mimetic peptide nanofiber gel improves regenerative healing of acute wounds

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buir.contributor.authorGüler, Mustafa O.
dc.citation.epage1303en_US
dc.citation.issueNumber7en_US
dc.citation.spage1296en_US
dc.citation.volumeNumber3en_US
dc.contributor.authorUzunalli, G.en_US
dc.contributor.authorMammadov R.en_US
dc.contributor.authorYesildal, F.en_US
dc.contributor.authorAlhan, D.en_US
dc.contributor.authorOzturk, S.en_US
dc.contributor.authorOzgurtas, T.en_US
dc.contributor.authorGüler, Mustafa O.en_US
dc.contributor.authorTekinay, A. B.en_US
dc.date.accessioned2018-04-12T11:08:35Z
dc.date.available2018-04-12T11:08:35Z
dc.date.issued2017en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractWound repair in adult mammals typically ends with the formation of a scar, which prevents full restoration of the function of the healthy tissue, although most of the wounded skin heals. Rapid and functional recovery of major wound injuries requires therapeutic approaches that can enhance the healing process via overcoming mechanical and biochemical problems. In this study, we showed that self-assembled heparin-mimetic peptide nanofiber gel was an effective bioactive wound dressing for the rapid and functional repair of full-thickness excisional wounds in the rat model. The bioactive gel-treated wounds exhibited increased angiogenesis (p < 0.05), re-epithelization (p < 0.05), skin appendage formation, and granulation tissue organization (p < 0.05) compared to sucrose-treated samples. Increased blood vessel numbers in the gel-treated wounds on day 7 suggest that angiogenesis played a key role in improvement of tissue healing in bioactive gel-treated wounds. Overall, the angiogenic heparin-mimetic peptide nanofiber gel is a promising platform for enhancing the scar-free recovery of acute wounds.en_US
dc.description.provenanceMade available in DSpace on 2018-04-12T11:08:35Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2017en
dc.identifier.doi10.1021/acsbiomaterials.6b00165en_US
dc.identifier.issn2373-9878
dc.identifier.urihttp://hdl.handle.net/11693/37283
dc.language.isoEnglishen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttps://doi.org/10.1021/acsbiomaterials.6b00165en_US
dc.source.titleACS Biomaterials Science and Engineeringen_US
dc.subjectAngiogenesisen_US
dc.subjectHeparin-mimetic peptide nanofiberen_US
dc.subjectSelf-assemblyen_US
dc.subjectWound healingen_US
dc.subjectAmphophileen_US
dc.subjectHeparinen_US
dc.subjectHeparin mimetic peptide nanofiberen_US
dc.subjectNanofiberen_US
dc.subjectPeptidomimetic agenten_US
dc.subjectUnclassified drugen_US
dc.subjectWound healing promoting agenten_US
dc.subjectAngiogenesisen_US
dc.subjectAnimal experimenten_US
dc.subjectAnimal modelen_US
dc.subjectAnimal tissueen_US
dc.subjectArticleen_US
dc.subjectBlood vesselen_US
dc.subjectControlled studyen_US
dc.subjectEpithelizationen_US
dc.subjectFemaleen_US
dc.subjectGelen_US
dc.subjectGranulation tissueen_US
dc.subjectHistologyen_US
dc.subjectIn vivo studyen_US
dc.subjectMaleen_US
dc.subjectNonhumanen_US
dc.subjectPriority journalen_US
dc.subjectRaten_US
dc.subjectScar formationen_US
dc.subjectSkin appendageen_US
dc.subjectSkin injuryen_US
dc.subjectVascularizationen_US
dc.subjectWound closureen_US
dc.subjectWound healingen_US
dc.titleAngiogenic heparin-mimetic peptide nanofiber gel improves regenerative healing of acute woundsen_US
dc.typeArticleen_US

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