Simulation of an integrated microfluidic device for bioparticle wash, separation and concentration

Simple item page
dc.contributor.authorÇetin, Barbarosen_US
dc.contributor.authorBüyükkoçak, S.en_US
dc.contributor.authorZeinali, Soheilaen_US
dc.contributor.authorÖzer, B.en_US
dc.coverage.spatialHong Kong, Chinaen_US
dc.date.accessioned2016-02-08T12:09:32Z
dc.date.available2016-02-08T12:09:32Z
dc.date.issued2013en_US
dc.departmentDepartment of Mechanical Engineeringen_US
dc.descriptionDate of Conference: December 11–14, 2013en_US
dc.descriptionConference name: Proceedings of the ASME 2013 4th International Conference on Micro/Nanoscale Heat and Mass Transfer MNHMT2013en_US
dc.description.abstractWashing, separation and concentration of bioparticles are key operations for many biological and chemical analyses. In this study, the simulation of an integrated microfluidic device is studied. The proposed device has the capability to wash the bioparticles (transferring the bioparticles from one buffer solution to another), to separate the particles based on their dielectric properties and to concentrate the bioparticles. Washing and concentration of bioparticles are performed by acoustophoresis and the separation is performed by dielectrophoresis. For simulating the flow within the microchannel, a computational fluid dynamics model using COMSOL Multiphysics software is implemented. In order to simulate the particle trajectories under ultrasonic and electric field, point-particle assumption is chosen using MATLAB software. To account for the size variation of the bioparticles, particles with normal size distributions are used in-side the microchannel. The effect of the key design parameters such as flow rate, applied voltage etc. on the performance of the device is discussed. Copyright © 2013 by ASME.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T12:09:32Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2013en
dc.identifier.doi10.1115/MNHMT2013-22181en_US
dc.identifier.urihttp://hdl.handle.net/11693/28045
dc.language.isoEnglishen_US
dc.publisherAmerican Society of Mechanical Engineers (ASME)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1115/MNHMT2013-22181en_US
dc.source.titleASME 2013 4th International Conference on Micro/Nanoscale Heat and Mass Transferen_US
dc.subjectChemical analysisen_US
dc.subjectComputational fluid dynamicsen_US
dc.subjectDielectric propertiesen_US
dc.subjectElectric fieldsen_US
dc.subjectElectrophoresisen_US
dc.subjectFluidic devicesen_US
dc.subjectHeat transferen_US
dc.subjectMass transferen_US
dc.subjectMATLABen_US
dc.subjectMicrochannelsen_US
dc.subjectWashingen_US
dc.subjectApplied voltagesen_US
dc.subjectBuffer solutionsen_US
dc.subjectComputational fluid dynamics modelingen_US
dc.subjectComsol multiphysicsen_US
dc.subjectIntegrated microfluidic devicesen_US
dc.subjectKey design parametersen_US
dc.subjectMatlab- softwareen_US
dc.subjectParticle trajectoriesen_US
dc.subjectBiological materialsen_US
dc.titleSimulation of an integrated microfluidic device for bioparticle wash, separation and concentrationen_US
dc.typeConference Paperen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Simulation_of_an_integrated_microfluidic_device_for_bioparticle_wash,_separation_and_concentration.pdf
Size:
1.57 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Scholarly Publications - Mechanical Engineering