Evaluation of chimerism with DNA polymorphisms in bone marrow transplantation

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dc.citation.epage311en_US
dc.citation.issueNumber3en_US
dc.citation.spage303en_US
dc.citation.volumeNumber39en_US
dc.contributor.authorÖzbek, U.en_US
dc.contributor.authorVural, B.en_US
dc.contributor.authorKalayoǧlu, S.en_US
dc.contributor.authorSoysal, T.en_US
dc.contributor.authorBilgen, H.en_US
dc.contributor.authorYavuz, S.en_US
dc.contributor.authorAnak, S.en_US
dc.contributor.authorSargın, D.en_US
dc.contributor.authorGedikoǧlu G.en_US
dc.contributor.authorFerhanoǧlu, Burhanen_US
dc.contributor.authorAkoǧlu, T.en_US
dc.contributor.authorTangün, Y.en_US
dc.contributor.authorÖzçelik, Tayfunen_US
dc.date.accessioned2016-02-08T10:46:55Z
dc.date.available2016-02-08T10:46:55Z
dc.date.issued1997en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractEvaluation of chimeric status following allogenlc BMT is an Important tool for monitoring the replacement of host cells with donor cells and for determining the risk of relapse. Polymorphic DNA sequences can be used as powerful markers in identification of donor/recipient genotype differences, even between close relatives. Polymerase chain reaction (PCR) amplification of three variable number of tandem repeat (VNTR) loci and five single-locus polymorphisms (SLP) was used to identify chimerism in 40 recipient-donor pairs. Mixed chimerism was present in 11 patients, and complete chimerism in 29. This PCR method is a rapid and sensitive assay to detect engraftment and evaluate relapse potential, and thus is very useful in the clinical management of BMT patients.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:46:55Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 1997en
dc.identifier.issn0041-4301
dc.identifier.urihttp://hdl.handle.net/11693/25567
dc.language.isoEnglishen_US
dc.publisherInternational Children's Center (I C C)en_US
dc.source.titleTurkish Journal of Pediatricsen_US
dc.subjectBone marrow transplantationen_US
dc.subjectChimerismen_US
dc.subjectPolymerase chain reactionen_US
dc.subjectPolymorphismen_US
dc.subjectRelapseen_US
dc.subjectVNTRen_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectBone marrow transplantationen_US
dc.subjectChilden_US
dc.subjectChimeraen_US
dc.subjectFemaleen_US
dc.subjectGenetic markeren_US
dc.subjectGenetic polymorphismen_US
dc.subjectPreschool childen_US
dc.subjectVariable number of tandem repeaten_US
dc.subjectAdolescenten_US
dc.subjectChild, Preschoolen_US
dc.subjectChimeraen_US
dc.subjectGenetic Markersen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectMinisatellite Repeatsen_US
dc.subjectPolymorphism, geneticen_US
dc.titleEvaluation of chimerism with DNA polymorphisms in bone marrow transplantationen_US
dc.typeArticleen_US

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