Self-assembled proteins and peptides as scaffolds for tissue regeneration

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buir.contributor.authorGüler, Mustafa O.
dc.citation.epage2586en_US
dc.citation.issueNumber16en_US
dc.citation.spage2557en_US
dc.citation.volumeNumber4en_US
dc.contributor.authorLoo, Y.en_US
dc.contributor.authorGoktas, M.en_US
dc.contributor.authorTekinay, A. B.en_US
dc.contributor.authorGüler, Mustafa O.en_US
dc.contributor.authorHauser, C. A. E.en_US
dc.contributor.authorMitraki, A.en_US
dc.date.accessioned2016-02-08T10:59:48Z
dc.date.available2016-02-08T10:59:48Z
dc.date.issued2015en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractSelf-assembling proteins and peptides are increasingly gaining interest for potential use as scaffolds in tissue engineering applications. They self-organize from basic building blocks under mild conditions into supramolecular structures, mimicking the native extracellular matrix. Their properties can be easily tuned through changes at the sequence level. Moreover, they can be produced in sufficient quantities with chemical synthesis or recombinant technologies to allow them to address homogeneity and standardization issues required for applications. Here. recent advances in self-assembling proteins, peptides, and peptide amphiphiles that form scaffolds suitable for tissue engineering are reviewed. The focus is on a variety of motifs, ranging from minimalistic dipeptides, simplistic ultrashort aliphatic peptides, and peptide amphiphiles to large "recombinamer" proteins. Special emphasis is placed on the rational design of self-assembling motifs and biofunctionalization strategies to influence cell behavior and modulate scaffold stability. Perspectives for combination of these "bottom-up" designer strategies with traditional "top-down" biofabrication techniques for new generations of tissue engineering scaffolds are highlighted. Recent advances in self-assembling proteins, peptides, and peptide amphiphiles that form scaffolds suitable for tissue engineering are discussed. Rational design and biofunctionalization strategies for a variety of motifs ranging from minimalistic dipeptides, ultrashort aliphatic peptides, and peptide amphiphiles to large "recombinamer" proteins are reviewed and challenges and perspectives for their widespread adoption in applications are highlighted.en_US
dc.identifier.doi10.1002/adhm.201500402en_US
dc.identifier.issn2192-2640
dc.identifier.urihttp://hdl.handle.net/11693/26441
dc.language.isoEnglishen_US
dc.publisherWiley-VCH Verlagen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/adhm.201500402en_US
dc.source.titleAdvanced Healthcare Materialsen_US
dc.subjectPeptidesen_US
dc.subjectProteinsen_US
dc.subjectRational designen_US
dc.subjectScaffoldsen_US
dc.subjectSelf-assemblyen_US
dc.subjectTissue engineeringen_US
dc.titleSelf-assembled proteins and peptides as scaffolds for tissue regenerationen_US
dc.typeArticleen_US

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Institute of Materials Science and Nanotechnology (UNAM)