Fast-dissolving electrospun gelatin nanofibers encapsulating ciprofloxacin/cyclodextrin inclusion complex

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buir.contributor.authorAytaç, Zeynep
buir.contributor.authorİpek, Semran
buir.contributor.authorDurgun, Engin
buir.contributor.authorUyar, Tamer
buir.contributor.orcidUyar, Tamer|0000-0002-3989-4481
dc.citation.epage136en_US
dc.citation.spage129en_US
dc.citation.volumeNumber178en_US
dc.contributor.authorAytaç, Zeynepen_US
dc.contributor.authorİpek, Semranen_US
dc.contributor.authorErol, I.en_US
dc.contributor.authorDurgun, Enginen_US
dc.contributor.authorUyar, Tameren_US
dc.date.accessioned2020-01-28T06:37:22Z
dc.date.available2020-01-28T06:37:22Z
dc.date.issued2019
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractElectrospun gelatin nanofibrous matrix encapsulating ciprofloxacin (CIP)/hydroxypropyl-beta-cyclodextrin (HPβCD)-inclusion complex (IC) was produced via electrospinning method. Computational modeling indicated that van der Waals forces are the most significant driving forces for the complexation and hydrophobic moiety (piperazinyl) of CIP, which was included in the cavity of HPβCD. The FTIR and XRD studies indicated the formation of CIP/HPβCD host/guest complexation, FTIR also suggested that hydrophobic moiety of CIP is in the HPβCD cavity in parallel with the computational modeling results. The phase solubility diagram demonstrated that the solubility of CIP was enhanced after complexation with HPβCD. SEM images showed that electrospun gelatin nanofibers encapsulating CIP/HPβCD-IC have bead-free morphology with a diameter of ˜90 nm. The gelatin nanofibrous mat loaded with CIP/HPβCD-IC has exhibited fast-dissolving character in water compared to gelatin/CIP nanofibrous mat due to the enhanced wettability of the nanofibrous mat by HPβCD and improvement achieved in the solubility of CIP.en_US
dc.embargo.release2021-06-01
dc.identifier.doi10.1016/j.colsurfb.2019.02.059en_US
dc.identifier.issn0927-7765
dc.identifier.urihttp://hdl.handle.net/11693/52853
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttps://dx.doi.org/10.1016/j.colsurfb.2019.02.059en_US
dc.source.titleColloids and Surfaces B: Biointerfacesen_US
dc.subjectElectrospinningen_US
dc.subjectNanofibersen_US
dc.subjectCiprofloxacinen_US
dc.subjectHydroxypropyl-beta-cyclodextrin (HPβCD)en_US
dc.subjectInclusion complexen_US
dc.subjectComputational modelingen_US
dc.titleFast-dissolving electrospun gelatin nanofibers encapsulating ciprofloxacin/cyclodextrin inclusion complexen_US
dc.typeArticleen_US

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Institute of Materials Science and Nanotechnology (UNAM)
Nanotechnology Research Center (NANOTAM)