Microfluidic device for synthesis of chitosan nanoparticles

Date
2013
Advisor
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Source Title
Proceedings of the ASME 2013 Fluids Engineering Division Summer Meeting
Print ISSN
0888-8116
Electronic ISSN
Publisher
ASME
Volume
2
Issue
Pages
Language
English
Type
Conference Paper
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Abstract

Chitosan nanoparticles have a biodegradable, biocompatible, non-toxic structure, and commonly used for drug delivery systems. In this paper, simulation of a microfluidic device for the synthesis of chitosan nanoparticle is presented. The flow filed together with the concentration field within the microchannel network is simulated using COMSOL Multiphysics® simulation environment. Different microchannel geometries are analyzed, and the mixing performance of these configurations are compared. As a result, a 3D design for a microfluidics platform which includes four channel each of which performs the synthesis in parallel is proposed. Future research directions regarding the fabrication of the microfluidic device and experimentation phase are addressed and discussed. Copyright © 2013 by ASME.

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Keywords
Chitosan nanoparticles, Concentration fields, Drug delivery system, Future research directions, Micro-fluidic devices, Microchannel geometries, Microchannel network, Simulation environment, Biocompatibility, Drug delivery, Fluidic devices, Microfluidics, Multiphase flow, Nanoparticles, Chitosan
Citation
Published Version (Please cite this version)