Detecting secondary structure and surface orientation of helical peptide monolayers from resonant hybridization signals

Date
2013
Authors
Alici, K. B.
Gallardo I.F.
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Source Title
Scientific Reports
Print ISSN
20452322
Electronic ISSN
Publisher
Nature Publishing Group
Volume
3
Issue
Pages
Language
English
Type
Article
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Abstract

Hybridization of dominant vibrational modes with meta-surface resonance allows detection of both structural changes and surface orientations of bound helical peptides. Depending on the resonance frequency of meta-molecules, a red- or blue- shift in peptide Amide-I frequency is observed. The underlying coupling mechanism is described by using a temporal coupled mode theory that is in very good agreement with the experimental results. This hybridization phenomenon constitutes the basis of many nanophotonic systems such as tunable coupled mode bio-sensors and dynamic peptide systems driven by infrared signals.

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Keywords
amide, peptide, algorithm, article, atomic force microscopy, chemical structure, chemistry, infrared spectrophotometry, protein secondary structure, Algorithms, Amides, Microscopy, Atomic Force, Models, Molecular, Peptides, Protein Structure, Secondary, Spectrophotometry, Infrared
Citation
Published Version (Please cite this version)