Synthesis of novel substituted purine derivatives and identification of the cell death mechanism

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dc.citation.epage720en_US
dc.citation.spage701en_US
dc.citation.volumeNumber89en_US
dc.contributor.authorDemir, Z.en_US
dc.contributor.authorGuven, E.B.en_US
dc.contributor.authorOzbey, S.en_US
dc.contributor.authorKazak, C.en_US
dc.contributor.authorAtalay, R.C.en_US
dc.contributor.authorTuncbilek, M.en_US
dc.date.accessioned2016-02-08T10:03:30Z
dc.date.available2016-02-08T10:03:30Z
dc.date.issued2015en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractNovel substituted adenine and purine derivatives were designed and synthesized.Compound 36 displayed the greatest cytotoxic activity with IC50 less than 1 1/4M.36 induces senescence associated cell death, which was demonstrated with SA2-Gal assay. © 2014 Elsevier Masson SAS.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:03:30Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2015en
dc.identifier.doi10.1016/j.ejmech.2014.10.080en_US
dc.identifier.issn2235234
dc.identifier.urihttp://hdl.handle.net/11693/22691
dc.language.isoEnglishen_US
dc.publisherElsevier Masson SASen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.ejmech.2014.10.080en_US
dc.source.titleEuropean Journal of Medicinal Chemistryen_US
dc.subjectAdenineen_US
dc.subjectCytotoxic activityen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectPurine derivativesen_US
dc.subjectSenescenceen_US
dc.subjectantineoplastic agenten_US
dc.subjectpurineen_US
dc.subjectpurine derivativeen_US
dc.subjectcell deathen_US
dc.subjectcell proliferationen_US
dc.subjectchemical structureen_US
dc.subjectchemistryen_US
dc.subjectdose responseen_US
dc.subjectdrug effectsen_US
dc.subjectdrug screeningen_US
dc.subjectHCT116 cell lineen_US
dc.subjectHepG2 cell lineen_US
dc.subjecthumanen_US
dc.subjectstructure activity relationen_US
dc.subjectsynthesisen_US
dc.subjecttumor cell cultureen_US
dc.subjectAntineoplastic Agentsen_US
dc.subjectCell Deathen_US
dc.subjectCell Proliferationen_US
dc.subjectDose-Response Relationship, Drugen_US
dc.subjectDrug Screening Assays, Antitumoren_US
dc.subjectHCT116 Cellsen_US
dc.subjectHep G2 Cellsen_US
dc.subjectHumansen_US
dc.subjectModels, Molecularen_US
dc.subjectMolecular Structureen_US
dc.subjectPurinesen_US
dc.subjectStructure-Activity Relationshipen_US
dc.subjectTumor Cells, Cultureden_US
dc.titleSynthesis of novel substituted purine derivatives and identification of the cell death mechanismen_US
dc.typeArticleen_US

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