Synthesis of novel substituted purine derivatives and identification of the cell death mechanism

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Synthesis of novel substituted purine derivatives and identification of the cell death mechanism.pdf (5.82 MB)

Date

2015

Authors

Demir, Z.
Guven, E.B.
Ozbey, S.
Kazak, C.
Atalay, R.C.
Tuncbilek, M.

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Abstract

Novel substituted adenine and purine derivatives were designed and synthesized.Compound 36 displayed the greatest cytotoxic activity with IC50 less than 1 1/4M.36 induces senescence associated cell death, which was demonstrated with SA2-Gal assay. © 2014 Elsevier Masson SAS.

Source Title

European Journal of Medicinal Chemistry

Publisher

Elsevier Masson SAS

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Keywords

Adenine, Cytotoxic activity, Hepatocellular carcinoma, Purine derivatives, Senescence, antineoplastic agent, purine, purine derivative, cell death, cell proliferation, chemical structure, chemistry, dose response, drug effects, drug screening, HCT116 cell line, HepG2 cell line, human, structure activity relation, synthesis, tumor cell culture, Antineoplastic Agents, Cell Death, Cell Proliferation, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, HCT116 Cells, Hep G2 Cells, Humans, Models, Molecular, Molecular Structure, Purines, Structure-Activity Relationship, Tumor Cells, Cultured

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http://hdl.handle.net/11693/22691

Published Version (Please cite this version)

http://dx.doi.org/10.1016/j.ejmech.2014.10.080

Collections

Scholarly Publications - Molecular Biology and Genetics

Language

English

Type

Article