Synthesis of novel substituted purine derivatives and identification of the cell death mechanism
Date
2015
Authors
Demir, Z.
Guven, E.B.
Ozbey, S.
Kazak, C.
Atalay, R.C.
Tuncbilek, M.
Editor(s)
Advisor
Supervisor
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Co-Supervisor
Instructor
Source Title
European Journal of Medicinal Chemistry
Print ISSN
2235234
Electronic ISSN
Publisher
Elsevier Masson SAS
Volume
89
Issue
Pages
701 - 720
Language
English
Type
Journal Title
Journal ISSN
Volume Title
Series
Abstract
Novel substituted adenine and purine derivatives were designed and synthesized.Compound 36 displayed the greatest cytotoxic activity with IC50 less than 1 1/4M.36 induces senescence associated cell death, which was demonstrated with SA2-Gal assay. © 2014 Elsevier Masson SAS.
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Book Title
Keywords
Adenine , Cytotoxic activity , Hepatocellular carcinoma , Purine derivatives , Senescence , antineoplastic agent , purine , purine derivative , cell death , cell proliferation , chemical structure , chemistry , dose response , drug effects , drug screening , HCT116 cell line , HepG2 cell line , human , structure activity relation , synthesis , tumor cell culture , Antineoplastic Agents , Cell Death , Cell Proliferation , Dose-Response Relationship, Drug , Drug Screening Assays, Antitumor , HCT116 Cells , Hep G2 Cells , Humans , Models, Molecular , Molecular Structure , Purines , Structure-Activity Relationship , Tumor Cells, Cultured