Synthesis of novel substituted purine derivatives and identification of the cell death mechanism
Date
2015
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Abstract
Novel substituted adenine and purine derivatives were designed and synthesized.Compound 36 displayed the greatest cytotoxic activity with IC50 less than 1 1/4M.36 induces senescence associated cell death, which was demonstrated with SA2-Gal assay. © 2014 Elsevier Masson SAS.
Source Title
European Journal of Medicinal Chemistry
Publisher
Elsevier Masson SAS
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Keywords
Adenine, Cytotoxic activity, Hepatocellular carcinoma, Purine derivatives, Senescence, antineoplastic agent, purine, purine derivative, cell death, cell proliferation, chemical structure, chemistry, dose response, drug effects, drug screening, HCT116 cell line, HepG2 cell line, human, structure activity relation, synthesis, tumor cell culture, Antineoplastic Agents, Cell Death, Cell Proliferation, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, HCT116 Cells, Hep G2 Cells, Humans, Models, Molecular, Molecular Structure, Purines, Structure-Activity Relationship, Tumor Cells, Cultured
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Language
English