Biocompatible supramolecular catalytic one-dimensional nanofibers for efficient labeling of live cells

Date
2015
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Source Title
Bioconjugate Chemistry
Print ISSN
1043-1802
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Publisher
American Chemical Society
Volume
26
Issue
12
Pages
2371 - 2375
Language
English
Type
Article
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Abstract

Understanding complex cellular functions requires study and tracking of biomolecules such as proteins, glycans, and lipids in their natural environment. Herein, we report the first supramolecular nanocatalyst for bioorthogonal click reaction to label live cells. This biocompatible and biodegradable nanocatalyst was formed by self-assembled peptide nanofibers complexed with copper ions. The supramolecular nanocatalyst enhanced azide-alkyne cycloaddition reaction rate under physiological conditions and was shown to be useful for efficient bioorthogonal labeling of live cells.

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Keywords
Alkyne, Amphophile, Azide, Copper ion, Nanofiber, Article, Cell function, Cell labeling, Chemical reaction, Click chemistry, Controlled study, Cycloaddition, Cytotoxicity, Nanocatalyst, Supramolecular chemistry
Citation
Published Version (Please cite this version)