Biocompatible supramolecular catalytic one-dimensional nanofibers for efficient labeling of live cells

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Abstract

Understanding complex cellular functions requires study and tracking of biomolecules such as proteins, glycans, and lipids in their natural environment. Herein, we report the first supramolecular nanocatalyst for bioorthogonal click reaction to label live cells. This biocompatible and biodegradable nanocatalyst was formed by self-assembled peptide nanofibers complexed with copper ions. The supramolecular nanocatalyst enhanced azide-alkyne cycloaddition reaction rate under physiological conditions and was shown to be useful for efficient bioorthogonal labeling of live cells.

Source Title

Bioconjugate Chemistry

Publisher

American Chemical Society

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Citation

Published Version (Please cite this version)

Language

English