Glycosylated porphyrin-cucurbituril conjugate for photodynamic inactivation of bacteria and doxorubicin carriage for anticancer drug delivery

Abstract

Porphyrin derivatives are highly attractive in the construction of multifunctional molecular platforms with interesting properties and applications. In this regard, we report here the use of a multifunctional porphyrin-based molecular platform as a photosensitizer for photodynamic therapy and as a drug carrier. This molecular platform was constructed by conjugating a host molecule, cucurbit[7]uril to a triglycosylated tetraphenyl porphyrin and serves very efficiently as a photosensitizer in the inactivation of both gram-negative (Escherichia coli, E. coli) and gram-positive bacteria (Bacillus subtilis, B. subtilis) and growth inhibition of cancer cells as well as a doxorubicin (DOX) carrier for chemo-photodynamic dual cancer therapy. Another remarkable feature of this photosensitizer is that it shows negligible cytotoxicity in the dark.