Fiber laser-microscope system for femtosecond photodisruption of biological samples

Simple item page
buir.contributor.authorYavaş, Seydi
buir.contributor.authorErdoğan, Mutlu
buir.contributor.authorGürel, Kutan
buir.contributor.authorİlday, F. Ömer
buir.contributor.authorTazebay, Uygar H.
dc.citation.epage611en_US
dc.citation.issueNumber3en_US
dc.citation.spage605en_US
dc.citation.volumeNumber3en_US
dc.contributor.authorYavaş, Seydien_US
dc.contributor.authorErdoğan, Mutluen_US
dc.contributor.authorGürel, Kutanen_US
dc.contributor.authorİlday, F. Ömeren_US
dc.contributor.authorEldeniz, Y. B.en_US
dc.contributor.authorTazebay, Uygar H.en_US
dc.date.accessioned2016-02-08T09:48:04Z
dc.date.available2016-02-08T09:48:04Z
dc.date.issued2012-02-22en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentDepartment of Physicsen_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.departmentAdvanced Research Laboratories (ARL)
dc.description.abstractWe report on the development of a ultrafast fiber lasermicroscope system for femtosecond photodisruption of biological targets. A mode-locked Yb-fiber laser oscillator generates few-nJ pulses at 32.7 MHz repetition rate, amplified up to ~125 nJ at 1030 nm. Following dechirping in a grating compressor, ~240 fs-long pulses are delivered to the sample through a diffraction-limited microscope, which allows real-time imaging and control. The laser can generate arbitrary pulse patterns, formed by two acousto-optic modulators (AOM) controlled by a custom-developed fieldprogrammable gate array (FPGA) controller. This capability opens the route to fine optimization of the ablation processes and management of thermal effects. Sample position, exposure time and imaging are all computerized. The capability of the system to perform femtosecond photodisruption is demonstrated through experiments on tissue and individual cells.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T09:48:04Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2012en
dc.identifier.doi10.1364/BOE.3.000605en_US
dc.identifier.eissn2156-7085
dc.identifier.urihttp://hdl.handle.net/11693/21562
dc.language.isoEnglishen_US
dc.publisherOptical Society of Americaen_US
dc.relation.isversionofhttp://dx.doi.org/10.1364/BOE.3.000605en_US
dc.source.titleBiomedical Optics Expressen_US
dc.subjectFiber lasersen_US
dc.subjectField programmable gate arrays (FPGA)en_US
dc.subjectMode-locked fiber lasersen_US
dc.subjectTissueen_US
dc.subjectYtterbiumen_US
dc.subjectAblation processen_US
dc.subjectAcousto-optic modulatoren_US
dc.subjectArbitrary pulseen_US
dc.subjectBiological samplesen_US
dc.subjectBiological targetsen_US
dc.subjectDechirpingen_US
dc.subjectDiffraction limiteden_US
dc.subjectExposure-timeen_US
dc.subjectFemtosecondsen_US
dc.subjectGrating compressorsen_US
dc.subjectIndividual cellsen_US
dc.subjectMode-lockeden_US
dc.subjectPhotodisruptionen_US
dc.subjectRealtime imagingen_US
dc.subjectRepetition rateen_US
dc.subjectSample positionen_US
dc.subjectUltra-fasten_US
dc.subjectYb fiber lasersen_US
dc.subjectPulse generatorsen_US
dc.titleFiber laser-microscope system for femtosecond photodisruption of biological samplesen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Fiber_laser_microscope_system_for_femtosecond_photodisruption_of_biological_samples.pdf
Size:
2.35 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Scholarly Publications - UNAM
Scholarly Publications - ARL
Scholarly Publications - Molecular Biology and Genetics
Scholarly Publications - Physics