Amphiphilic peptide coated superparamagnetic iron oxide nanoparticles for in vivo MR tumor imaging

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buir.contributor.authorGüler, Mustafa O.
dc.citation.epage45146en_US
dc.citation.issueNumber51en_US
dc.citation.spage45135en_US
dc.citation.volumeNumber6en_US
dc.contributor.authorOzdemir, A.en_US
dc.contributor.authorEkiz, M. S.en_US
dc.contributor.authorDilli, A.en_US
dc.contributor.authorGüler, Mustafa O.en_US
dc.contributor.authorTekinay, A. B.en_US
dc.date.accessioned2018-04-12T10:48:07Z
dc.date.available2018-04-12T10:48:07Z
dc.date.issued2016en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractMagnetic resonance imaging (MRI) is a noninvasive imaging technique that provides high spatial resolution and depth with pronounced soft-tissue contrast for in vivo imaging. A broad variety of strategies have been employed to enhance the diagnostic value of MRI and detect tissue abnormalities at an earlier stage. Superparamagnetic iron oxide nanoparticles (SPIONs) are considered to be suitable candidates for effective imaging due to their small size, versatile functionality and better biocompatibility. Here, we demonstrate that coating SPIONs with proline-rich amphiphilic peptide molecules through noncovalent interactions leads to a water-dispersed hybrid system suitable as an MRI contrast agent. Cellular viability and uptake of amphiphilic peptide coated SPIONs (SPION/K-PA) were evaluated with human vascular endothelial cells (HUVEC) and estrogen receptor (ER) positive human breast adenocarcinoma (MCF-7) cells. The efficiency of SPION/K-PA as MRI contrast agents was analyzed in Sprague-Dawley rats with mammary gland tumors. MR imaging showed that SPION/K-PA effectively accumulated in tumor tissues, enhancing their imaging potential. Although nanoparticles were observed in reticuloendothelial system organs (RES) and especially in the liver and kidney immediately after administration, the MR signal intensity in these organs diminished after 1 h and nanoparticles were subsequently cleared from these organs within two weeks. Histological observations also validated the accumulation of nanoparticles in tumor tissue at 4 h and their bioelimination from the organs of both healthy and tumor-bearing rats after two weeks.en_US
dc.description.provenanceMade available in DSpace on 2018-04-12T10:48:07Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2016en
dc.identifier.doi10.1039/c6ra07380hen_US
dc.identifier.issn2046-2069
dc.identifier.urihttp://hdl.handle.net/11693/36677
dc.language.isoEnglishen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionofhttps://doi.org/10.1039/c6ra07380hen_US
dc.source.titleRSC Advancesen_US
dc.subjectBiocompatibilityen_US
dc.subjectDiagnosisen_US
dc.subjectEndothelial cellsen_US
dc.subjectHybrid systemsen_US
dc.subjectImaging techniquesen_US
dc.subjectIonsen_US
dc.subjectIron oxidesen_US
dc.subjectMetal nanoparticlesen_US
dc.subjectNanoparticlesen_US
dc.subjectPeptidesen_US
dc.subjectRatsen_US
dc.subjectSuperparamagnetismen_US
dc.subjectTissueen_US
dc.subjectTumorsen_US
dc.subjectAmphiphilic peptidesen_US
dc.subjectHigh spatial resolutionen_US
dc.subjectHistological observationsen_US
dc.subjectHuman vascular endothelial cellsen_US
dc.subjectNon-covalent interactionen_US
dc.subjectReticuloendothelial systemsen_US
dc.subjectSuperparamagnetic iron oxide nanoparticlesen_US
dc.subjectTissue abnormalitiesen_US
dc.subjectMagnetic resonance imagingen_US
dc.titleAmphiphilic peptide coated superparamagnetic iron oxide nanoparticles for in vivo MR tumor imagingen_US
dc.typeArticleen_US

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