“Off–on” switching of intracellular singlet oxygen release under biocompatible conditions
| buir.contributor.author | Uçar, Esma | |
| buir.contributor.author | Seven, Özlem | |
| buir.contributor.author | Cansu, Cansu | |
| buir.contributor.author | Akkaya, Engin U. | |
| dc.citation.epage | 13811 | en_US |
| dc.citation.issueNumber | 92 | en_US |
| dc.citation.spage | 13808 | en_US |
| dc.citation.volumeNumber | 55 | en_US |
| dc.contributor.author | Uçar, Esma | en_US |
| dc.contributor.author | Xi, D. | en_US |
| dc.contributor.author | Seven, Özlem | en_US |
| dc.contributor.author | Kaya, Cansu | en_US |
| dc.contributor.author | Peng, X. | en_US |
| dc.contributor.author | Sun, W. | en_US |
| dc.contributor.author | Akkaya, Engin U. | en_US |
| dc.date.accessioned | 2020-02-17T10:01:13Z | |
| dc.date.available | 2020-02-17T10:01:13Z | |
| dc.date.issued | 2019-10 | |
| dc.department | Department of Chemistry | en_US |
| dc.department | Institute of Materials Science and Nanotechnology (UNAM) | en_US |
| dc.description.abstract | Precise spatiotemporal control of singlet oxygen generation is of immense importance considering its involvement in photodynamic therapy. In this work, we present a rational design for an endoperoxide which is highly stable at ambient temperatures yet, can rapidly be converted into a highly labile endoperoxide, thus releasing the “stored” singlet oxygen on demand. The “off–on” chemical switching from the stable to the labile form is accomplished by the reaction with fluoride ions. The potential utility of controlled singlet oxygen release was demonstrated in cell cultures. | en_US |
| dc.description.provenance | Submitted by Evrim Ergin (eergin@bilkent.edu.tr) on 2020-02-17T10:01:13Z No. of bitstreams: 1 off-on_switching_of_intracellular_singlet_oxygen_release_under_biocompatible_conditions.pdf: 4234448 bytes, checksum: b35adcf14096f37b8ab9af3dcac6c17e (MD5) | en |
| dc.description.provenance | Made available in DSpace on 2020-02-17T10:01:13Z (GMT). No. of bitstreams: 1 off-on_switching_of_intracellular_singlet_oxygen_release_under_biocompatible_conditions.pdf: 4234448 bytes, checksum: b35adcf14096f37b8ab9af3dcac6c17e (MD5) Previous issue date: 2019-10 | en |
| dc.identifier.doi | 10.1039/c9cc06231a | en_US |
| dc.identifier.eissn | 1364-548X | |
| dc.identifier.uri | http://hdl.handle.net/11693/53388 | |
| dc.language.iso | English | en_US |
| dc.publisher | Royal Society of Chemistry | en_US |
| dc.relation.isversionof | https://dx.doi.org/10.1039/c9cc06231a | en_US |
| dc.source.title | Chemical Communications | en_US |
| dc.title | “Off–on” switching of intracellular singlet oxygen release under biocompatible conditions | en_US |
| dc.type | Article | en_US |