Selective photosensitization through an and logic response: optimization of the pH and glutathione response of activatable photosensitizers

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dc.citation.epage12261en_US
dc.citation.issueNumber61en_US
dc.citation.spage12258en_US
dc.citation.volumeNumber51en_US
dc.contributor.authorErbas-Cakmak, S.en_US
dc.contributor.authorCakmak, F. P.en_US
dc.contributor.authorTopel, S. D.en_US
dc.contributor.authorUyar, T. B.en_US
dc.contributor.authorAkkaya, E. U.en_US
dc.date.accessioned2016-02-08T09:45:04Z
dc.date.available2016-02-08T09:45:04Z
dc.date.issued2015en_US
dc.departmentDepartment of Chemistryen_US
dc.description.abstractA series of pH and GSH responsive photosensitizers were designed and synthesized. pK<inf>a</inf> values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0-7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.en_US
dc.identifier.doi10.1039/c5cc01261aen_US
dc.identifier.eissn1364-548X
dc.identifier.issn1359-7345
dc.identifier.urihttp://hdl.handle.net/11693/21347
dc.language.isoEnglishen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionofhttp://dx.doi.org/10.1039/c5cc01261aen_US
dc.source.titleChemical Communicationsen_US
dc.subjectpKaen_US
dc.titleSelective photosensitization through an and logic response: optimization of the pH and glutathione response of activatable photosensitizersen_US
dc.typeArticleen_US

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