Connections of the dentate nucleus with the amygdala: Experimental rat and human 3-tesla tractography study

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buir.contributor.authorAlgın, Oktay
buir.contributor.orcidAlgın, Oktay|0000-0002-3877-8366
dc.citation.epage913en_US
dc.citation.issueNumber10en_US
dc.citation.spage905en_US
dc.citation.volumeNumber12en_US
dc.contributor.authorÇavdar, S.
dc.contributor.authorGüneş, Y. C.
dc.contributor.authorAlgın, Oktay
dc.date.accessioned2023-02-27T08:07:47Z
dc.date.available2023-02-27T08:07:47Z
dc.date.issued2022-12-13
dc.departmentNational Magnetic Resonance Research Center (UMRAM)en_US
dc.description.abstractBackground: The role of the cerebellum in motor function is well recognized. However, its role in higher nervous system activities such as cognition, emotion, endocrine, and autonomic activities is less known. The present study aims to show direct dento-amygdala projections using a biotinylated dextran amine (BDA) tracer in rats and 3-tesla (T) high-resolution diffusion tensor imaging (DTI)-based tractography in humans. Materials and Methods: The BDA tracer was pressure injected into the dentate nucleus of the cerebellum of Wistar albino rats. Labeled cells and axons were documented. High-resolution 3-T tractography data were obtained from the Human Connectome Project database. Dento-amygdala tracts were analyzed using diffusion spectrum imaging (DSI) Studio software. Results: The experimental study showed bilateral projections between the dentate nucleus and the central and basal nuclei and ipsilateral projections between lateral nuclei of the amygdala. The fibers from the dentate nucleus reached the amygdala through the superior cerebellar peduncle (SCP), and the contralateral fibers crossed in the decussation of SCP at the midbrain. The dento-amygdala results of the experimental study corresponded with the 3-T tractography findings on humans. Additionally, DTI findings showed that most of the dentate fibers passed through the hypothalamus before reaching the amygdala, and the amygdalae of the two sides are connected through the anterior commissure. Discussion: The 3-T DTI data of adult humans showed both direct dento-amygdala and indirect dento-hypothalamo-amygdala projections. Thus, this may indicate cerebellar contribution in modulation of emotional and autonomic functions. Furthermore, this can explain the emotional and cognitive deficits that occur in patients with cerebellar or SCP damage.en_US
dc.identifier.doi10.1089/brain.2021.0179en_US
dc.identifier.eissn2158-0022
dc.identifier.issn2158-0014
dc.identifier.urihttp://hdl.handle.net/11693/111797
dc.language.isoEnglishen_US
dc.publisherMary Ann Liebert, Inc. Publishersen_US
dc.relation.isversionofhttps://doi.org/10.1089/brain.2021.0179en_US
dc.source.titleBrain Connectivityen_US
dc.subjectAmygdalaen_US
dc.subjectCerebellumen_US
dc.subjectConnectionsen_US
dc.subjectDTIen_US
dc.subjectTract-tracingen_US
dc.titleConnections of the dentate nucleus with the amygdala: Experimental rat and human 3-tesla tractography studyen_US
dc.typeArticleen_US

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