Noncovalent functionalization of mesoporous silica nanoparticles with amphiphilic peptides

Date
2014
Advisor
Instructor
Source Title
Journal of Materials Chemistry B
Print ISSN
20507518
Electronic ISSN
Publisher
Royal Society of Chemistry
Volume
2
Issue
15
Pages
2168 - 2174
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Abstract

The surface of mesoporous silica nanoparticles (MSNs) has been modified for enhancing their cellular uptake, cell targeting, bioimaging, and controlled drug release. For this purpose, covalent anchorage on the silica surface was predominantly exploited with a wide range of bioactive molecules. Here, we describe a facile self-assembly method to prepare a hybrid peptide silica system composed of octyl-modified mesoporous silica nanoparticles (MSNs) and peptide amphiphiles (PAs). The hydrophobic organosilane surface of mesoporous silica was coated with amphiphilic peptide molecules. The peptide functionalized particles exhibited good cyto-compatibility with vascular smooth muscle and vascular endothelial cells. The peptide coating also improved the cellular uptake of particles up to 6.3 fold, which is promising for the development of highly efficient MSN based theranostic agents. © 2014 the Partner Organisations.

Course
Other identifiers
Book Title
Keywords
Amphiphilic peptides, Controlled drug release, Functionalized particles, Mesoporous silica nanoparticles, Non-covalent functionalization, Self-assembly method, Vascular endothelial cells, Vascular smooth muscles, Endothelial cells, Polymer blends, Silica, Peptides
Citation
Published Version (Please cite this version)