Design and synthesis of monosaccharide functionalized conjugated polymers, polyrotaxanes and oligomers for biological applications

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buir.advisorTuncel, Dönüş
dc.contributor.authorSoner, Esra Deniz
dc.date.accessioned2016-04-29T12:55:26Z
dc.date.available2016-04-29T12:55:26Z
dc.date.copyright2015-09
dc.date.issued2015-09
dc.date.submitted01-10-2015
dc.departmentDepartment of Chemistryen_US
dc.descriptionCataloged from PDF version of thesis.en_US
dc.descriptionIncludes bibliographical references (leaves 76-81).en_US
dc.descriptionThesis (M.S.): Bilkent University, Department of Physics, İhsan Doğramacı Bilkent University, 2015.en_US
dc.description.abstractIn this work, the design, synthesis and characterization of fluorescent, water-soluble, multivalent glycoconjugates for their potential applications in active-targetted cellular theranostics through receptor-mediated endocytosis are presented. Gluco-functionalized thiophene monomers are utilized for the pre-functionalized Suzuki coupling polymerization of glycopolythiophenes and glycopolythiophenerotaxanes. The pre-functionalized glycopolythiophenerotaxane synthesis route was designed to provide in situ complexation between boronic ester thiophene monomer and water-soluble macrocycle cucurbit[7]uril, for the Suzuki coupling with the glycothiophene monomer in water. Red emitting oligomers carrying azide groups were utilized for the synthesis of post-functionalized glycoconjugate oligomers. These functionalizations were carried through 1,3-dipolar cycloaddition (click reaction) between azide groups and alkyne-functionalized monosaccharides (mannose or glucose). Structural and photophysical properties of glycopolythiophenes were investigated through ¹H-NMR, UV-VIS, and Fluorescence Spectroscopy. Monomers in synthetic steps were analysed through ¹H-NMR, IR, and ¹³C-NMR. Structural, photophysical and morphological properties of red oligomers were investigated through ¹H-NMR, HRMS-TOF, DLS, SEM.en_US
dc.description.degreeM.S.en_US
dc.description.provenanceSubmitted by Betül Özen (ozen@bilkent.edu.tr) on 2016-04-29T12:55:26Z No. of bitstreams: 1 EsraSonerTez.pdf: 4768467 bytes, checksum: 480034c14afe4f72800c2e30e3039d9e (MD5)en
dc.description.provenanceMade available in DSpace on 2016-04-29T12:55:26Z (GMT). No. of bitstreams: 1 EsraSonerTez.pdf: 4768467 bytes, checksum: 480034c14afe4f72800c2e30e3039d9e (MD5) Previous issue date: 2015-09en
dc.description.statementofresponsibilityby Esra Deniz Soner.en_US
dc.embargo.release2017-09-10
dc.format.extentxv, 81 leaves : charts.en_US
dc.identifier.itemidB151603
dc.identifier.urihttp://hdl.handle.net/11693/29018
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectConjugated polymersen_US
dc.subjectGlycoconjugateen_US
dc.subjectCucurbiturilen_US
dc.subjectPolyrotaxaneen_US
dc.subjectClick reactionen_US
dc.titleDesign and synthesis of monosaccharide functionalized conjugated polymers, polyrotaxanes and oligomers for biological applicationsen_US
dc.title.alternativeBiyolojik uygulamalara yönelik monosakkarit fonksiyonlu konjuge polimer, polirotaksan ve oligomerlerin tasarım ve sentezien_US
dc.typeThesisen_US

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