Structure, mechanism and therapeutic utility of immunosuppressive oligonucleotides

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dc.citation.epage225en_US
dc.citation.spage216en_US
dc.citation.volumeNumber105en_US
dc.contributor.authorBayik D.en_US
dc.contributor.authorGursel, I.en_US
dc.contributor.authorKlinman, D. M.en_US
dc.date.accessioned2018-04-12T10:53:24Z
dc.date.available2018-04-12T10:53:24Z
dc.date.issued2016en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractSynthetic oligodeoxynucleotides that can down-regulate cellular elements of the immune system have been developed and are being widely studied in preclinical models. These agents vary in sequence, mechanism of action, and cellular target(s) but share the ability to suppress a plethora of inflammatory responses. This work reviews the types of immunosuppressive oligodeoxynucleotide (Sup ODN) and compares their therapeutic activity against diseases characterized by pathologic levels of immune stimulation ranging from autoimmunity to septic shock to cancer (see graphical abstract). The mechanism(s) underlying the efficacy of Sup ODN and the influence size, sequence and nucleotide backbone on function are considered. © Published by Elsevier Ltd.en_US
dc.identifier.doi10.1016/j.phrs.2015.11.010en_US
dc.identifier.issn1043-6618
dc.identifier.urihttp://hdl.handle.net/11693/36789
dc.language.isoEnglishen_US
dc.publisherAcademic Pressen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.phrs.2015.11.010en_US
dc.source.titlePharmacological Researchen_US
dc.subjectCpG oligonucleotideen_US
dc.subjectDendritic cellen_US
dc.subjectIRF5en_US
dc.subjectIRF8en_US
dc.subjectTLR9en_US
dc.subjecta 151en_US
dc.subjectCpG oligodeoxynucleotideen_US
dc.subjectQuanine oligodeoxynucleotideen_US
dc.subjecth 154en_US
dc.subjectInhibitory oligodeoxynucleotideen_US
dc.subjectMicrosatellite oligodeoxynucleotideen_US
dc.subjectOligonucleotideen_US
dc.subjectSTAT proteinen_US
dc.subjectSuppressive oligodeoxynucleotideen_US
dc.subjectSynthetic oligonucleotideen_US
dc.subjectToll like receptor 4en_US
dc.subjectToll like receptor 7en_US
dc.subjectToll like receptor 9en_US
dc.subjectUnclassified drugen_US
dc.titleStructure, mechanism and therapeutic utility of immunosuppressive oligonucleotidesen_US
dc.typeArticleen_US

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