Structure, mechanism and therapeutic utility of immunosuppressive oligonucleotides

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Structure, mechanism and therapeutic utility of immunosuppressive oligonucleotides.pdf (1.33 MB)

Date

2016

Authors

Bayik D.
Gursel, I.
Klinman, D. M.

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Abstract

Synthetic oligodeoxynucleotides that can down-regulate cellular elements of the immune system have been developed and are being widely studied in preclinical models. These agents vary in sequence, mechanism of action, and cellular target(s) but share the ability to suppress a plethora of inflammatory responses. This work reviews the types of immunosuppressive oligodeoxynucleotide (Sup ODN) and compares their therapeutic activity against diseases characterized by pathologic levels of immune stimulation ranging from autoimmunity to septic shock to cancer (see graphical abstract). The mechanism(s) underlying the efficacy of Sup ODN and the influence size, sequence and nucleotide backbone on function are considered. © Published by Elsevier Ltd.

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Pharmacological Research

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Academic Press

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Keywords

CpG oligonucleotide, Dendritic cell, IRF5, IRF8, TLR9, a 151, CpG oligodeoxynucleotide, Quanine oligodeoxynucleotide, h 154, Inhibitory oligodeoxynucleotide, Microsatellite oligodeoxynucleotide, Oligonucleotide, STAT protein, Suppressive oligodeoxynucleotide, Synthetic oligonucleotide, Toll like receptor 4, Toll like receptor 7, Toll like receptor 9, Unclassified drug

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http://hdl.handle.net/11693/36789

Published Version (Please cite this version)

http://dx.doi.org/10.1016/j.phrs.2015.11.010

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Scholarly Publications - Molecular Biology and Genetics

Language

English

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Article