Structure, mechanism and therapeutic utility of immunosuppressive oligonucleotides

Date
2016
Authors
Bayik D.
Gursel, I.
Klinman, D. M.
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Source Title
Pharmacological Research
Print ISSN
1043-6618
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Publisher
Academic Press
Volume
105
Issue
Pages
216 - 225
Language
English
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Abstract

Synthetic oligodeoxynucleotides that can down-regulate cellular elements of the immune system have been developed and are being widely studied in preclinical models. These agents vary in sequence, mechanism of action, and cellular target(s) but share the ability to suppress a plethora of inflammatory responses. This work reviews the types of immunosuppressive oligodeoxynucleotide (Sup ODN) and compares their therapeutic activity against diseases characterized by pathologic levels of immune stimulation ranging from autoimmunity to septic shock to cancer (see graphical abstract). The mechanism(s) underlying the efficacy of Sup ODN and the influence size, sequence and nucleotide backbone on function are considered. © Published by Elsevier Ltd.

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Published Version (Please cite this version)