Biosystems engineering of prokaryotes with tumor-killing capacities

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dc.citation.epage1528en_US
dc.citation.issueNumber11en_US
dc.citation.spage1521en_US
dc.citation.volumeNumber22en_US
dc.contributor.authorKalyoncu, E.en_US
dc.contributor.authorOlmez, T. T.en_US
dc.contributor.authorOzkan, A. D.en_US
dc.contributor.authorSarioglu, O. F.en_US
dc.date.accessioned2018-04-12T10:46:26Z
dc.date.available2018-04-12T10:46:26Z
dc.date.issued2016en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractCertain bacteria selectively attack tumor tissues and trigger tumor shrinkage by producing toxins and modulating the local immune system, but their clinical utility is limited because of the dangers posed by systemic infection. Genetic engineering can be used to minimize the risks associated with tumor-targeting pathogens, as well as to increase their efficiency in killing tumor cells. Advances in genetic circuit design have led to the development of bacterial strains with enhanced tumor-targeting capacities and the ability to secrete therapeutics, cytotoxic proteins and prodrug-cleaving enzymes, which allows their safe and effective use for cancer treatment. The present review details the recent advances in the design and application of these modified bacterial strains.en_US
dc.description.provenanceMade available in DSpace on 2018-04-12T10:46:26Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2016en
dc.identifier.doi10.2174/1381612822666151210123752en_US
dc.identifier.eissn1873-4286en_US
dc.identifier.issn1381-6128
dc.identifier.urihttp://hdl.handle.net/11693/36631
dc.language.isoEnglishen_US
dc.publisherBentham Science Publishers Ltd.en_US
dc.relation.isversionofhttp://dx.doi.org/10.2174/1381612822666151210123752en_US
dc.source.titleCurrent Pharmaceutical Designen_US
dc.subjectBifidobacteriumen_US
dc.subjectCancer therapyen_US
dc.subjectClostridiumen_US
dc.subjectLive vaccinesen_US
dc.subjectProdrug cleavageen_US
dc.subjectSalmonellaen_US
dc.subjectSynthetic biologyen_US
dc.subjectAntineoplastic agenten_US
dc.subjectCytotoxic factoren_US
dc.subjectDrug carrieren_US
dc.subjectFlucytosineen_US
dc.subjectFluorouracilen_US
dc.subjectGancicloviren_US
dc.subjectLive vaccineen_US
dc.subjectProbiotic agenten_US
dc.subjectTretazicaren_US
dc.subjectUnclassified drugen_US
dc.subjectVnp 20009en_US
dc.subjectAntibiotic therapyen_US
dc.subjectAntineoplastic activityen_US
dc.subjectArticleen_US
dc.subjectBacterial membraneen_US
dc.subjectBacterial strainen_US
dc.subjectBifidobacteriumen_US
dc.subjectCancer diagnosisen_US
dc.subjectCancer recurrenceen_US
dc.subjectCancer therapyen_US
dc.subjectCD8+ T lymphocyteen_US
dc.subjectCell infiltrationen_US
dc.subjectClostridiumen_US
dc.subjectColony forming uniten_US
dc.subjectDrug activationen_US
dc.subjectDrug delivery systemen_US
dc.subjectEscherichiaen_US
dc.subjectGene transferen_US
dc.subjectGenetic engineeringen_US
dc.subjectImmune responseen_US
dc.subjectImmunogenicityen_US
dc.subjectMetastasisen_US
dc.subjectNatural killer T cellen_US
dc.subjectNonhumanen_US
dc.subjectOxygen concentrationen_US
dc.subjectPhase 2 clinical trial (topic)en_US
dc.subjectPriority journalen_US
dc.subjectProkaryoteen_US
dc.subjectSalmonellaen_US
dc.subjectTarget cellen_US
dc.subjectTumor microenvironmenten_US
dc.subjectType III secretion systemen_US
dc.subjectAnimalen_US
dc.subjectBacteriumen_US
dc.subjectBiological therapyen_US
dc.subjectCytologyen_US
dc.subjectGeneticsen_US
dc.subjectHumanen_US
dc.subjectMetabolismen_US
dc.subjectMicrobiologyen_US
dc.subjectNeoplasmsen_US
dc.subjectPathophysiologyen_US
dc.subjectProkaryotic cellen_US
dc.subjectAnimalsen_US
dc.subjectBacteriaen_US
dc.subjectBiological therapyen_US
dc.subjectHumansen_US
dc.subjectNeoplasmsen_US
dc.subjectProkaryotic cellsen_US
dc.titleBiosystems engineering of prokaryotes with tumor-killing capacitiesen_US
dc.typeArticleen_US

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