Implantable microelectromechanical sensors for diagnostic monitoring and post-surgical prediction of bone fracture healing

Date
2015
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Source Title
Journal of Orthopaedic Research
Print ISSN
0736-0266
Electronic ISSN
Publisher
John Wiley and Sons Inc.
Volume
33
Issue
10
Pages
1439 - 1446
Language
English
Type
Article
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Abstract

The relationship between modern clinical diagnostic data, such as from radiographs or computed tomography, and the temporal biomechanical integrity of bone fracture healing has not been well-established. A diagnostic tool that could quantitatively describe the biomechanical stability of the fracture site in order to predict the course of healing would represent a paradigm shift in the way fracture healing is evaluated. This paper describes the development and evaluation of a wireless, biocompatible, implantable, microelectromechanical system (bioMEMS) sensor, and its implementation in a large animal (ovine) model, that utilized both normal and delayed healing variants. The in vivo data indicated that the bioMEMS sensor was capable of detecting statistically significant differences (p-value <0.04) between the two fracture healing groups as early as 21 days post-fracture. In addition, post-sacrifice micro-computed tomography, and histology data demonstrated that the two model variants represented significantly different fracture healing outcomes, providing explicit supporting evidence that the sensor has the ability to predict differential healing cascades. These data verify that the bioMEMS sensor can be used as a diagnostic tool for detecting the in vivo course of fracture healing in the acute post-treatment period. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

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Keywords
Implanted, Biomechanics, Histology, Micro computed tomography, Microelectromechanical system (MEMS), Animal experiment, Animal model, Animal tissue, Biocompatibility, Biosensor, Controlled study, Diagnosis, Fracture healing, Histopathology, In vivo study, Micro - computed tomography, Microelectromechanical system, Molecular sensor, Nonhuman, Priority journal, Sheep, Statistical significance, Wound healing impairment, Ambulatory monitoring, Devices, Electrode implant, Evaluation study, Materials testing, Animals, Electrodes, Materials testing, Micro - electrical - mechanical systems, Monitoring, Telemetry
Citation
Published Version (Please cite this version)