A high-coverage genome sequence from an archaic Denisovan individual

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dc.citation.epage226en_US
dc.citation.issueNumber6104en_US
dc.citation.spage222en_US
dc.citation.volumeNumber338en_US
dc.contributor.authorMeyer, M.en_US
dc.contributor.authorKircher, M.en_US
dc.contributor.authorGansauge, Marie-Theresen_US
dc.contributor.authorLi, H.en_US
dc.contributor.authorRacimo, F.en_US
dc.contributor.authorMallick, S.en_US
dc.contributor.authorSchraiber, J. G.en_US
dc.contributor.authorJay, F.en_US
dc.contributor.authorPrüfer, K.en_US
dc.contributor.authorFilippo, Cesare deen_US
dc.contributor.authorSudmant, P. H.en_US
dc.contributor.authorAlkan C.en_US
dc.contributor.authorFu, Q.en_US
dc.contributor.authorDo, R.en_US
dc.contributor.authorRohland, N.en_US
dc.contributor.authorTandon, A.en_US
dc.contributor.authorSiebauer, M.en_US
dc.contributor.authorGreen, R. E.en_US
dc.contributor.authorBryc, K.en_US
dc.contributor.authorBriggs, A. W.en_US
dc.contributor.authorStenzel, U.en_US
dc.contributor.authorDabney, J.en_US
dc.contributor.authorShendure, J.en_US
dc.contributor.authorKitzman, J.en_US
dc.contributor.authorHammer, M. F.en_US
dc.contributor.authorShunkov, M. V.en_US
dc.contributor.authorDerevianko, A. P.en_US
dc.contributor.authorPatterson, N.en_US
dc.contributor.authorAndrés, A. M.en_US
dc.contributor.authorEichler, E. E.en_US
dc.contributor.authorSlatkin, M.en_US
dc.contributor.authorReich, D.en_US
dc.contributor.authorKelso, J.en_US
dc.contributor.authorPääbo, S.en_US
dc.date.accessioned2016-02-08T09:44:24Z
dc.date.available2016-02-08T09:44:24Z
dc.date.issued2012-10-12en_US
dc.departmentDepartment of Computer Engineeringen_US
dc.description.abstractWe present a DNA library preparation method that has allowed us to reconstruct a high-coverage (30x) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality of this genome allows a direct estimation of Denisovan heterozygosity indicating that genetic diversity in these archaic hominins was extremely low. It also allows tentative dating of the specimen on the basis of "missing evolution" in its genome, detailed measurements of Denisovan and Neandertal admixture into present-day human populations, and the generation of a near-complete catalog of genetic changes that swept to high frequency in modern humans since their divergence from Denisovans.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T09:44:24Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2012en
dc.identifier.doi10.1126/science.1224344en_US
dc.identifier.issn0036-8075en_US
dc.identifier.urihttp://hdl.handle.net/11693/21297en_US
dc.language.isoEnglishen_US
dc.publisherAmerican Association for the Advancement of Science (A A A S)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1126/science.1224344en_US
dc.source.titleScienceen_US
dc.subjectDNAen_US
dc.subjectGenetic analysisen_US
dc.subjectGenomeen_US
dc.subjectHeterozygosityen_US
dc.subjectNeanderthalen_US
dc.subjectDenisovanen_US
dc.subjectDNA libraryen_US
dc.subjectGene sequenceen_US
dc.subjectGenetic variabilityen_US
dc.subjectHeterozygosityen_US
dc.subjectHomo neanderthalensisen_US
dc.subjectHumanen_US
dc.subjectPriority journalen_US
dc.titleA high-coverage genome sequence from an archaic Denisovan individualen_US
dc.typeArticleen_US

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