A high-coverage genome sequence from an archaic Denisovan individual

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A high-coverage genome sequence from an archaic Denisovan individual.pdf (263.37 KB)

Date

2012-10-12

Authors

Meyer, M.
Kircher, M.
Gansauge, Marie-Theres
Li, H.
Racimo, F.
Mallick, S.
Schraiber, J. G.
Jay, F.
Prüfer, K.
Filippo, Cesare de

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Source Title

Science

Print ISSN

0036-8075

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Publisher

American Association for the Advancement of Science (A A A S)

Volume

338

Issue

6104

Pages

222 - 226

Language

English

Type

Article

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Abstract

We present a DNA library preparation method that has allowed us to reconstruct a high-coverage (30x) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality of this genome allows a direct estimation of Denisovan heterozygosity indicating that genetic diversity in these archaic hominins was extremely low. It also allows tentative dating of the specimen on the basis of "missing evolution" in its genome, detailed measurements of Denisovan and Neandertal admixture into present-day human populations, and the generation of a near-complete catalog of genetic changes that swept to high frequency in modern humans since their divergence from Denisovans.

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Keywords

DNA, Genetic analysis, Genome, Heterozygosity, Neanderthal, Denisovan, DNA library, Gene sequence, Genetic variability, Heterozygosity, Homo neanderthalensis, Human, Priority journal

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Permalink

http://hdl.handle.net/11693/21297

Published Version (Please cite this version)

http://dx.doi.org/10.1126/science.1224344

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Scholarly Publications - Computer Engineering