Molecular encapsulation of cinnamaldehyde within cyclodextrin inclusion complex electrospun nanofibers: fast-dissolution, enhanced water solubility, high temperature stability, and antibacterial activity of cinnamaldehyde

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buir.contributor.authorYıldız, Zehra İrem
buir.contributor.authorKılıç, Mehmet Emin
buir.contributor.authorDurgun, Engin
buir.contributor.authorUyar, Tamer
buir.contributor.orcidUyar, Tamer|0000-0002-3989-4481
dc.citation.epage11076en_US
dc.citation.issueNumber40en_US
dc.citation.spage11066en_US
dc.citation.volumeNumber67en_US
dc.contributor.authorYıldız, Zehra İremen_US
dc.contributor.authorKılıç, Mehmet Eminen_US
dc.contributor.authorDurgun, Enginen_US
dc.contributor.authorUyar, Tameren_US
dc.date.accessioned2020-02-14T09:27:35Z
dc.date.available2020-02-14T09:27:35Z
dc.date.issued2019
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractThe electrospinning of nanofibers (NFs) of cinnamaldehyde inclusion complexes (ICs) with two different hydroxypropylated cyclodextrins (CDs), hydroxypropyl-β-cyclodextrin (HP-β-CD) and hydroxypropyl-γ-cyclodextrin (HP-γ-CD), was successfully performed in order to produce cinnamaldehyde/CD-IC NFs without using an additional polymer matrix. The inclusion complexation between cinnamaldehyde and hydroxypropylated CDs was studied by computational molecular modeling, and the results suggested that HP-β-CD and HP-γ-CD can be inclusion complexed with cinnamaldehyde at 1:1 and 2:1 (cinnamaldehyde/CD) molar ratios. Additionally, molecular modeling and phase solubility studies showed that water solubility of cinnamaldehyde dramatically increases with cyclodextrin inclusion complex (CD-IC) formation. The HP-β-CD has shown slightly stronger binding with cinnamaldehyde when compared to HP-γ-CD for cinnamaldehyde/CD-IC. Although cinnamaldehyde is a highly volatile compound, it was effectively preserved with high loading by the cinnamaldehyde/CD-IC NFs. It was also observed that cinnamaldehyde has shown much higher temperature stability in cinnamaldehyde/CD-IC NFs compared to uncomplexed cinnamaldehyde because of the inclusion complexation state of cinnamaldehyde within the hydroxypropylated CD cavity. Moreover, cinnamaldehyde still has kept its antibacterial activity in cinnamaldehyde/CD-IC NF samples when tested against Escherichia coli. In addition, cinnamaldehyde/CD-IC NF mats were fast-dissolving in water, even though pure cinnamaldehyde has a water-insoluble nature. In brief, self-standing nanofibrous mats of electrospun cinnamaldehyde/CD-IC NFs are potentially applicable in food, oral-care, healthcare, and pharmaceutics because of their fast-dissolving character, enhanced water solubility, stability at elevated temperature, and promising antibacterial activity.en_US
dc.identifier.doi10.1021/acs.jafc.9b02789en_US
dc.identifier.issn0021-8561
dc.identifier.urihttp://hdl.handle.net/11693/53358
dc.language.isoEnglishen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttps://dx.doi.org/10.1021/acs.jafc.9b02789en_US
dc.source.titleJournal of Agricultural and Food Chemistryen_US
dc.subjectAntibacterial activityen_US
dc.subjectCinnamaldehydeen_US
dc.subjectCyclodextrin inclusion complexesen_US
dc.subjectCyclodextrinsen_US
dc.subjectElectrospinningen_US
dc.subjectFast-dissolvingen_US
dc.subjectHigh temperature stabilityen_US
dc.subjectNanofibersen_US
dc.subjectWater solubilityen_US
dc.titleMolecular encapsulation of cinnamaldehyde within cyclodextrin inclusion complex electrospun nanofibers: fast-dissolution, enhanced water solubility, high temperature stability, and antibacterial activity of cinnamaldehydeen_US
dc.typeArticleen_US

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Institute of Materials Science and Nanotechnology (UNAM)
Nanotechnology Research Center (NANOTAM)