The effect of SARS-CoV-2 virus on resting-state functional connectivity during adolescence: Investigating brain correlates of psychotic-like experiences and SARS-CoV-2 related inflammation response

buir.contributor.authorDasgin, Hacer
buir.contributor.authorSahin Cevik, Didenur
buir.contributor.authorOguz, Kader K.
buir.contributor.authorToulopoulou, Timothea
buir.contributor.orcidOguz, Kader K.|0000-0002-3385-4665
dc.citation.epage111746-8en_US
dc.citation.spage111746-1
dc.citation.volumeNumber336
dc.contributor.authorYilmaz Kafali, H.
dc.contributor.authorDasgin, Hacer
dc.contributor.authorSahin Cevik, Didenur
dc.contributor.authorSozan, S. S.
dc.contributor.authorOguz, Kader K.
dc.contributor.authorMutlu, M.
dc.contributor.authorOzkaya Parlakay, A.
dc.contributor.authorToulopoulou, Timothea
dc.date.accessioned2024-03-11T05:54:01Z
dc.date.available2024-03-11T05:54:01Z
dc.date.issued2023-12
dc.departmentNational Magnetic Resonance Research Center (UMRAM)
dc.departmentDepartment of Philosophy
dc.description.abstractWe first aimed to investigate resting-state functional connectivity (rs-FC) differences between adolescents exposed to SARS-CoV-2 and healthy controls. Secondly, the moderator effect of PLEs on group differences in rs-FC was examined. Thirdly, brain correlates of inflammation response during acute SARS-CoV-2 infection were investigated. Eighty-two participants aged between 14 and 24 years (SARS-CoV-2 (n = 35), controls (n = 47)) were examined using rs-fMRI. Seed-based rs-FC analysis was performed. The positive subscale of Community Assessment of Psychotic Experiences-42 (CAPE-Pos) was used to measure PLEs. The SARS-CoV-2 group had a lesser rs-FC within sensorimotor network (SMN), central executive network (CEN) and language network (LN), but an increased rs-FC within visual network (VN) compared to controls. No significant differences were detected between the groups regarding CAPE-Pos-score. However, including CAPE-Pos as a covariate, we found increased rs-FC within CEN and SN in SARS-CoV-2 compared to controls. Among the SARS-CoV-2 group, neutrophil/lymphocyte and thrombocyte*neutrophil/lymphocyte ratio was correlated with decreased/increased FC within DMN and SN, and increased FC within CEN. Our results showed rs-FC alterations within the SMN, CEN, LN, and VN among adolescents exposed to SARS-CoV-2. Moreover, changes in rs-FC associated with PLEs existed in these adolescents despite the absence of clinical changes. Furthermore, inflammation response was correlated with alterations in FC within the triple network system.
dc.description.provenanceMade available in DSpace on 2024-03-11T05:54:01Z (GMT). No. of bitstreams: 1 The_effect_of_SARS-CoV-2_virus_on_resting-state_functional_connectivity_during_adolescence_Investigating_brain_correlates_of_psychotic-like_experiences_and_SARS-CoV-2_related_inflammation_response.pdf: 1780552 bytes, checksum: c91ca02235982a3811a1c097e97d0cfe (MD5) Previous issue date: 2023-12en
dc.identifier.doi10.1016/j.pscychresns.2023.111746
dc.identifier.eissn1872-7506
dc.identifier.issn0925-4927
dc.identifier.urihttps://hdl.handle.net/11693/114465
dc.language.isoen_US
dc.publisherElsevier B.V.
dc.relation.isversionofhttps://doi.org/10.1016/j.pscychresns.2023.111746
dc.rightsCC BY 4.0 Deed (Attribution 4.0 International)
dc.rights.urihttps://creativecommons.org/licenses/by/2.0/
dc.source.titlePsychiatry Research: Neuroimaging
dc.subjectCOVID-19
dc.subjectPsychosis proneness
dc.subjectNeuroimaging
dc.subjectFunctional connectivity
dc.subjectAdolescent
dc.subjectInflammation markers
dc.subjectBrain networks
dc.titleThe effect of SARS-CoV-2 virus on resting-state functional connectivity during adolescence: Investigating brain correlates of psychotic-like experiences and SARS-CoV-2 related inflammation response
dc.typeArticle

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