Chitosan scaffolds with BMP-6 loaded alginate microspheres for periodontal tissue engineering
dc.citation.epage | 780 | en_US |
dc.citation.issueNumber | 8 | en_US |
dc.citation.spage | 770 | en_US |
dc.citation.volumeNumber | 29 | en_US |
dc.contributor.author | Soran, Z. | en_US |
dc.contributor.author | Aydin, R.S.T. | en_US |
dc.contributor.author | Gumusderelioglu, M. | en_US |
dc.date.accessioned | 2016-02-08T09:42:57Z | |
dc.date.available | 2016-02-08T09:42:57Z | |
dc.date.issued | 2012 | en_US |
dc.department | Department of Chemistry | en_US |
dc.description.abstract | The aim of this study is to develop an effective growth factor releasing scaffold-microsphere system for promoting periodontal tissue engineering. Bone morphogenetic protein-6 (BMP-6)-loaded alginate microspheres in narrow size distribution were produced by optimising electrospraying conditions. The addition of these microspheres to chitosan gels produced a novel scaffold in which not only the pore sizes and interconnectivity were preserved, but also a controlled release vehicle was generated. Loading capacity was adjusted as 50ng or 100ng BMP-6 for each scaffold and the controlled release behaviour of BMP-6 from chitosan scaffolds was observed during seven days. Cell culture studies were carried out with rat mesenchymal stem cells derived from bone marrow in three groups; chitosan scaffolds, chitosan scaffolds containing BMP-6-loaded alginate microspheres and chitosan scaffolds with free BMP-6 in culture medium. Results showed that controlled delivery of BMP-6 from alginate microspheres has a significant effect on osteogenic differentiation. © 2012 Informa UK Ltd All rights reserved. | en_US |
dc.description.provenance | Made available in DSpace on 2016-02-08T09:42:57Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2012 | en |
dc.identifier.doi | 10.3109/02652048.2012.686531 | en_US |
dc.identifier.issn | 0265-2048 | |
dc.identifier.uri | http://hdl.handle.net/11693/21201 | |
dc.language.iso | English | en_US |
dc.relation.isversionof | http://dx.doi.org/10.3109/02652048.2012.686531 | en_US |
dc.source.title | Journal of Microencapsulation | en_US |
dc.subject | Alginate microspheres | en_US |
dc.subject | BMP-6 | en_US |
dc.subject | Chitosan scaffold | en_US |
dc.subject | Mesenchymal stem cells | en_US |
dc.subject | Periodontal tissue engineering | en_US |
dc.subject | alginic acid | en_US |
dc.subject | bone morphogenetic protein 6 | en_US |
dc.subject | chitosan | en_US |
dc.subject | microsphere | en_US |
dc.subject | animal cell | en_US |
dc.subject | article | en_US |
dc.subject | bone marrow | en_US |
dc.subject | cell culture | en_US |
dc.subject | cell differentiation | en_US |
dc.subject | controlled release formulation | en_US |
dc.subject | culture medium | en_US |
dc.subject | drug release | en_US |
dc.subject | electrospray | en_US |
dc.subject | mesenchymal stem cell | en_US |
dc.subject | nonhuman | en_US |
dc.subject | periodontium | en_US |
dc.subject | rat | en_US |
dc.subject | tissue engineering | en_US |
dc.subject | Alginates | en_US |
dc.subject | Animals | en_US |
dc.subject | Bone Morphogenetic Protein 6 | en_US |
dc.subject | Chitosan | en_US |
dc.subject | Culture Media | en_US |
dc.subject | Glucuronic Acid | en_US |
dc.subject | Hexuronic Acids | en_US |
dc.subject | Mesenchymal Stromal Cells | en_US |
dc.subject | Microscopy, Electron, Scanning | en_US |
dc.subject | Microspheres | en_US |
dc.subject | Periodontium | en_US |
dc.subject | Rats | en_US |
dc.subject | Tissue Engineering | en_US |
dc.title | Chitosan scaffolds with BMP-6 loaded alginate microspheres for periodontal tissue engineering | en_US |
dc.type | Article | en_US |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- Chitosan scaffolds with BMP-6 loaded alginate microspheres for periodontal tissue engineering.pdf
- Size:
- 1.52 MB
- Format:
- Adobe Portable Document Format
- Description:
- Full printable version