Self-powered disposable prothrombin time measurement device with an integrated effervescent pump

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buir.contributor.authorIşıksaçan, Ziya
buir.contributor.authorSerhatlıoğlu, Murat
buir.contributor.authorElbüken, Çağlar
dc.citation.epage357en_US
dc.citation.spage350en_US
dc.citation.volumeNumber273en_US
dc.contributor.authorGüler, M. T.en_US
dc.contributor.authorIşıksaçan, Ziyaen_US
dc.contributor.authorSerhatlıoğlu, Muraten_US
dc.contributor.authorElbüken, Çağlaren_US
dc.date.accessioned2019-02-21T16:02:00Z
dc.date.available2019-02-21T16:02:00Z
dc.date.issued2018en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractCoagulation is an essential physiological activity initiated by the interaction of blood components for clot formation. Prothrombin time (PT) measurement is a clinical test for the assessment of the extrinsic/common pathways of coagulation cascade. Periodic measurement of PT is required under numerous conditions including cardiovascular disorders. We present a self-powered microfluidic device for quantitative PT measurement from 50 μl whole blood. The entire platform is disposable and does not require any external pumping, power, or readout units. It consists of a 3D-printed effervescent pump for CO2 generation from a chemical reaction, a cartridge for two-channel fluid flow (blood and water), and a grid for the quantification of fluid migration distance. Following the introduction of the fluids to the corresponding channel inlets, marking the coagulation start, an acid-base reaction is triggered for gas generation that drives the fluids within the channels. When the blood coagulates, its flow in the channel is halted. At that point, the distance water has travelled is measured using the grid. This distance correlates with PT as demonstrated through clinical tests with patient samples. This single-unit device has a potential for rapid evaluation and periodic monitoring of PT in the clinical settings and at the point-of-care.
dc.description.provenanceMade available in DSpace on 2019-02-21T16:02:00Z (GMT). No. of bitstreams: 1 Bilkent-research-paper.pdf: 222869 bytes, checksum: 842af2b9bd649e7f548593affdbafbb3 (MD5) Previous issue date: 2018en
dc.description.sponsorshipThe authors thank Prof. Ozcan Erel for the clinical tests and Dr. Ismail Bilican for the comments on the manuscript. Ziya Isiksacan is supported by ASELSAN Graduate Scholarship for Turkish Academicians . The authors acknowledge support from The Scientific and Technologic Research Council of Turkey (TUBITAK project no. 213S127 ).
dc.embargo.release2020-11-10en_US
dc.identifier.doi10.1016/j.snb.2018.06.042
dc.identifier.issn0925-4005
dc.identifier.urihttp://hdl.handle.net/11693/49950
dc.language.isoEnglish
dc.publisherElsevier B.V.
dc.relation.isversionofhttps://doi.org/10.1016/j.snb.2018.06.042
dc.relation.projectASELSAN - 213S127
dc.source.titleSensors and Actuators, B: Chemicalen_US
dc.subject3D printingen_US
dc.subjectChemical pumpen_US
dc.subjectCoagulationen_US
dc.subjectMicrofluidicsen_US
dc.subjectPoint-Of-Careen_US
dc.subjectProthrombin timeen_US
dc.titleSelf-powered disposable prothrombin time measurement device with an integrated effervescent pumpen_US
dc.typeArticleen_US

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