Biological properties of extracellular vesicles and their physiological functions

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dc.citation.epage60en_US
dc.citation.issueNumber1en_US
dc.citation.spage1en_US
dc.citation.volumeNumber4en_US
dc.contributor.authorYáñez-Mó, M.en_US
dc.contributor.authorSiljander, P. R. M.en_US
dc.contributor.authorAndreu, Z.en_US
dc.contributor.authorZavec, A. B.en_US
dc.contributor.authorBorràs, F. E.en_US
dc.contributor.authorBuzas, E. I.en_US
dc.contributor.authorBuzas, K.en_US
dc.contributor.authorCasal, E.en_US
dc.contributor.authorCappello, F.en_US
dc.contributor.authorCarvalho, J.en_US
dc.contributor.authorColás, E.en_US
dc.contributor.authorCordeiro-Da, S. A.en_US
dc.contributor.authorFais, S.en_US
dc.contributor.authorFalcon-Perez, J. M.en_US
dc.contributor.authorGhobrial, I. M.en_US
dc.contributor.authorGiebel, B.en_US
dc.contributor.authorGimona, M.en_US
dc.contributor.authorGraner, M.en_US
dc.contributor.authorGursel, I.en_US
dc.contributor.authorGursel, M.en_US
dc.contributor.authorHeegaard, N. H. H.en_US
dc.contributor.authorHendrix, A.en_US
dc.contributor.authorKierulf, P.en_US
dc.contributor.authorKokubun, K.en_US
dc.contributor.authorKosanovic, M.en_US
dc.contributor.authorKralj-Iglic, V.en_US
dc.contributor.authorKrämer-Albers, E. M.en_US
dc.contributor.authorLaitinen, S.en_US
dc.contributor.authorLässer, C.en_US
dc.contributor.authorLener, T.en_US
dc.contributor.authorLigeti, E.en_US
dc.contributor.authorLine, A.en_US
dc.contributor.authorLipps, G.en_US
dc.contributor.authorLlorente, A.en_US
dc.contributor.authorLötvall, J.en_US
dc.contributor.authorManček-Keber, M.en_US
dc.contributor.authorMarcilla, A.en_US
dc.contributor.authorMittelbrunn, M.en_US
dc.contributor.authorNazarenko, I.en_US
dc.contributor.authorNolte-'t Hoen, E. N. M.en_US
dc.contributor.authorNyman, T. A.en_US
dc.contributor.authorO'Driscoll, L.en_US
dc.contributor.authorOlivan, M.en_US
dc.contributor.authorOliveira, C.en_US
dc.contributor.authorPállinger, E.en_US
dc.contributor.authorDel Portillo, H. A.en_US
dc.contributor.authorReventós, J.en_US
dc.contributor.authorRigau, M.en_US
dc.contributor.authorRohde, E.en_US
dc.contributor.authorSammar, M.en_US
dc.contributor.authorSánchez-Madrid, F.en_US
dc.contributor.authorSantarém, N.en_US
dc.contributor.authorSchallmoser, K.en_US
dc.contributor.authorOstenfeld, M. S.en_US
dc.contributor.authorStoorvogel, W.en_US
dc.contributor.authorStukelj, R.en_US
dc.contributor.authorGrein V. D. S.G.en_US
dc.contributor.authorHelena,ü V. M.en_US
dc.contributor.authorWauben, M. H. M.en_US
dc.contributor.authorDe Wever, O.en_US
dc.date.accessioned2018-04-12T13:53:32Z
dc.date.available2018-04-12T13:53:32Z
dc.date.issued2015en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractIn the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells.While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.en_US
dc.description.provenanceMade available in DSpace on 2018-04-12T13:53:32Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2015en
dc.identifier.doi10.3402/jev.v4.27066en_US
dc.identifier.issn2001-3078
dc.identifier.urihttp://hdl.handle.net/11693/38337
dc.language.isoEnglishen_US
dc.publisherTaylor & Francisen_US
dc.relation.isversionofhttp://dx.doi.org/10.3402/jev.v4.27066en_US
dc.source.titleJournal of Extracellular Vesiclesen_US
dc.subjectEukaryoteen_US
dc.subjectExosomeen_US
dc.subjectExtracellular vesicleen_US
dc.subjectMicroparticleen_US
dc.subjectMicrovesicleen_US
dc.subjectPhysiologyen_US
dc.subjectProkaryoteen_US
dc.subjectCytokineen_US
dc.subjectDNAen_US
dc.subjectLectinen_US
dc.subjectLipiden_US
dc.subjectMembrane receptoren_US
dc.subjectMicroRNAen_US
dc.subjectMorphogenen_US
dc.subjectRNAen_US
dc.subjectAdaptive immunityen_US
dc.subjectAmnion fluiden_US
dc.subjectAntigen presenting cellen_US
dc.subjectBileen_US
dc.subjectBiofilmen_US
dc.subjectBiogenesisen_US
dc.subjectBiologyen_US
dc.subjectBlooden_US
dc.subjectBlood clottingen_US
dc.subjectBody fluiden_US
dc.subjectBone mineralizationen_US
dc.subjectBreast milken_US
dc.subjectCell communicationen_US
dc.subjectCell functionen_US
dc.subjectCell interactionen_US
dc.subjectCell selectionen_US
dc.subjectCell transporten_US
dc.subjectCellular distributionen_US
dc.subjectCerebrospinal fluiden_US
dc.subjectDNA contenten_US
dc.subjectEmbryo developmenten_US
dc.subjectExosomeen_US
dc.subjectFecesen_US
dc.subjectHumanen_US
dc.subjectInnate immunityen_US
dc.subjectLiver metabolismen_US
dc.subjectLung lavageen_US
dc.subjectMacrophageen_US
dc.subjectMale genital systemen_US
dc.subjectMast cellen_US
dc.subjectMembrane vesicleen_US
dc.subjectMesenchymal stem cellen_US
dc.subjectMicroorganismen_US
dc.subjectMolecular biologyen_US
dc.subjectMonocyteen_US
dc.subjectNatural killer cellen_US
dc.subjectNervous systemen_US
dc.subjectNeutrophilen_US
dc.subjectNonhumanen_US
dc.subjectNose mucusen_US
dc.subjectPlanten_US
dc.subjectPregnancyen_US
dc.subjectProtein glycosylationen_US
dc.subjectProtein processingen_US
dc.subjectProteomicsen_US
dc.subjectReticulocyteen_US
dc.subjectReviewen_US
dc.subjectRNA analysisen_US
dc.subjectRNA transporten_US
dc.subjectSalivaen_US
dc.subjectSeminal plasmaen_US
dc.subjectStressen_US
dc.subjectSynovial fluiden_US
dc.subjectT lymphocyteen_US
dc.subjectTissue repairen_US
dc.subjectUrineen_US
dc.subjectUterus fluiden_US
dc.subjectVascular biologyen_US
dc.subjectEukaryotaen_US
dc.subjectProkaryotaen_US
dc.titleBiological properties of extracellular vesicles and their physiological functionsen_US
dc.typeArticleen_US

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