Biological properties of extracellular vesicles and their physiological functions

Date
2015
Authors
Yáñez-Mó, M.
Siljander, P. R. M.
Andreu, Z.
Zavec, A. B.
Borràs, F. E.
Buzas, E. I.
Buzas, K.
Casal, E.
Cappello, F.
Carvalho, J.
Advisor
Supervisor
Co-Advisor
Co-Supervisor
Instructor
Source Title
Journal of Extracellular Vesicles
Print ISSN
2001-3078
Electronic ISSN
Publisher
Taylor & Francis
Volume
4
Issue
1
Pages
1 - 60
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Series
Abstract

In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells.While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.

Course
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Keywords
Eukaryote, Exosome, Extracellular vesicle, Microparticle, Microvesicle, Physiology, Prokaryote, Cytokine, DNA, Lectin, Lipid, Membrane receptor, MicroRNA, Morphogen, RNA, Adaptive immunity, Amnion fluid, Antigen presenting cell, Bile, Biofilm, Biogenesis, Biology, Blood, Blood clotting, Body fluid, Bone mineralization, Breast milk, Cell communication, Cell function, Cell interaction, Cell selection, Cell transport, Cellular distribution, Cerebrospinal fluid, DNA content, Embryo development, Exosome, Feces, Human, Innate immunity, Liver metabolism, Lung lavage, Macrophage, Male genital system, Mast cell, Membrane vesicle, Mesenchymal stem cell, Microorganism, Molecular biology, Monocyte, Natural killer cell, Nervous system, Neutrophil, Nonhuman, Nose mucus, Plant, Pregnancy, Protein glycosylation, Protein processing, Proteomics, Reticulocyte, Review, RNA analysis, RNA transport, Saliva, Seminal plasma, Stress, Synovial fluid, T lymphocyte, Tissue repair, Urine, Uterus fluid, Vascular biology, Eukaryota, Prokaryota
Citation
Published Version (Please cite this version)