Electrospinning of cyclodextrin functional nanofibers for drug delivery applications

Simple item page
buir.contributor.authorTopuz, Fuat
buir.contributor.authorUyar, Tamer
buir.contributor.orcidUyar, Tamer|0000-0002-3989-4481
dc.citation.issueNumber1en_US
dc.citation.volumeNumber11en_US
dc.contributor.authorTopuz, Fuaten_US
dc.contributor.authorUyar, Tameren_US
dc.date.accessioned2020-01-24T11:05:26Z
dc.date.available2020-01-24T11:05:26Z
dc.date.issued2019
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractElectrospun nanofibers have sparked tremendous attention in drug delivery since they can offer high specific surface area, tailored release of drugs, controlled surface chemistry for preferred protein adsorption, and tunable porosity. Several functional motifs were incorporated into electrospun nanofibers to greatly expand their drug loading capacity or to provide the sustained release of the embedded drug molecules. In this regard, cyclodextrins (CyD) are considered as ideal drug carrier molecules as they are natural, edible, and biocompatible compounds with a truncated cone-shape with a relatively hydrophobic cavity interior for complexation with hydrophobic drugs and a hydrophilic exterior to increase the water-solubility of drugs. Further, the formation of CyD-drug inclusion complexes can protect drug molecules from physiological degradation, or elimination and thus increases the stability and bioavailability of drugs, of which the release takes place with time, accompanied by fiber degradation. In this review, we summarize studies related to CyD-functional electrospun nanofibers for drug delivery applications. The review begins with an introductory description of electrospinning; the structure, properties, and toxicology of CyD; and CyD-drug complexation. Thereafter, the release of various drug molecules from CyD-functional electrospun nanofibers is provided in subsequent sections. The review concludes with a summary and outlook on material strategiesen_US
dc.identifier.doi10.3390/pharmaceutics11010006en_US
dc.identifier.issn1999-4923
dc.identifier.urihttp://hdl.handle.net/11693/52805
dc.language.isoEnglishen_US
dc.publisherMDPI AGen_US
dc.relation.isversionofhttps://doi.org/10.3390/pharmaceutics11010006en_US
dc.source.titlePharmaceuticsen_US
dc.subjectElectrospinningen_US
dc.subjectDrug deliveryen_US
dc.subjectNanofibersen_US
dc.subjectCyclodextrin-inclusion complexesen_US
dc.subjectEssential oilsen_US
dc.subjectElectrospun nanofibersen_US
dc.subjectPoly-cyclodextrinen_US
dc.subjectAntibacterialen_US
dc.subjectAntibioticsen_US
dc.titleElectrospinning of cyclodextrin functional nanofibers for drug delivery applicationsen_US
dc.typeReviewen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Electrospinning_of_cyclodextrin_functional_nanofibers_for_drug_delivery_applications.pdf
Size:
10.49 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Institute of Materials Science and Nanotechnology (UNAM)