Advances in biosensor technologies for acute kidney injury

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buir.contributor.authorDerin, Esma
buir.contributor.authorİnci, Fatih
buir.contributor.orcidDerin, Esma|0000-0002-9626-2843
buir.contributor.orcidİnci, Fatih0000-0002-9918-5038|
dc.citation.epage385en_US
dc.citation.issueNumber2
dc.citation.spage358en_US
dc.citation.volumeNumber7
dc.contributor.authorDerin, Esma
dc.contributor.authorİnci, Fatih
dc.date.accessioned2022-02-04T12:58:00Z
dc.date.available2022-02-04T12:58:00Z
dc.date.issued2021-12-20
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractAcute kidney injury (AKI) is one of the most prevalent and complex clinical syndromes with high morbidity and mortality. The traditional diagnosis parameters are insufficient regarding specificity and sensitivity, and therefore, novel biomarkers and their facile and rapid applications are being sought to improve the diagnostic procedures. The biosensors, which are employed on the basis of electrochemistry, plasmonics, molecular probes, and nanoparticles, are the prominent ways of developing point-of-care devices, along with the mutual integration of efficient surface chemistry strategies. In this manner, biosensing platforms hold pivotal significance in detecting and quantifying novel AKI biomarkers to improve diagnostic interventions, potentially accelerating clinical management to control the injury in a timely manner. In this review, novel diagnostic platforms and their manufacturing processes are presented comprehensively. Furthermore, strategies to boost their effectiveness are also indicated with several applications. To maximize these efforts, we also review various biosensing approaches with a number of biorecognition elements (e.g., antibodies, aptamers, and molecular imprinting molecules), as well as benchmark their features such as robustness, stability, and specificity of these platforms.en_US
dc.identifier.doi10.1021/acssensors.1c01781en_US
dc.identifier.eissn2379-3694
dc.identifier.urihttp://hdl.handle.net/11693/77049
dc.language.isoEnglishen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttps://doi.org/10.1021/acssensors.1c01781en_US
dc.source.titleACS Sensorsen_US
dc.subjectAcute kidney injury (AKI)en_US
dc.subjectAKI biomarkersen_US
dc.subjectEarly diagnosisen_US
dc.subjectPoint-of care (POC)en_US
dc.subjectBiosensorsen_US
dc.subjectElectrochemical biosensorsen_US
dc.subjectPlasmonic biosensoren_US
dc.subjectNanoparticlesen_US
dc.subjectMolecular probesen_US
dc.subjectCommercial testsen_US
dc.titleAdvances in biosensor technologies for acute kidney injuryen_US
dc.typeReviewen_US

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Institute of Materials Science and Nanotechnology (UNAM)