The optomotor response of aging zebrafish reveals a complex relationship between visual motion characteristics and cholinergic system

buir.contributor.authorKaraduman, Ayşenur
buir.contributor.authorKaroğlu-Eravşar, Elif Tuğçe
buir.contributor.authorKaya, Utku
buir.contributor.authorAydın, Alaz
buir.contributor.authorAdams, Michelle
buir.contributor.authorKafalıgönül, Hulusi
buir.contributor.orcidKaroğlu-Eravşar, Elif Tuğçe|0000-0001-5110-3956
buir.contributor.orcidKaya, Utku|0000-0001-6127-2761
buir.contributor.orcidAydın, Alaz|0000-0002-0931-3455
dc.citation.epage32en_US
dc.citation.spage21en_US
dc.citation.volumeNumber98en_US
dc.contributor.authorKaraduman, Ayşenur
dc.contributor.authorKaroğlu-Eravşar, Elif Tuğçe
dc.contributor.authorKaya, Utku
dc.contributor.authorAydın, Alaz
dc.contributor.authorAdams, Michelle
dc.contributor.authorKafalıgönül, Hulusi
dc.date.accessioned2022-02-23T08:30:47Z
dc.date.available2022-02-23T08:30:47Z
dc.date.issued2020-10-23
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.departmentDepartment of Psychologyen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNational Magnetic Resonance Research Center (UMRAM)en_US
dc.description.abstractUnderstanding the principles underlying age-related changes in motion perception is paramount for improving the quality of life and health of older adults. However, the mechanisms underlying age-related alterations in this aspect of vision, which is essential for survival in a dynamic world, still remain unclear. Using optomotor responses to drifting gratings, we investigated age-related changes in motion detection of adult zebrafish (wild-type/AB-strain and achesb55/+ mutants with decreased levels of acetylcholinesterase). Our results pointed out negative optomotor responses that significantly depend on the spatial frequency and contrast level of stimulation, providing supporting evidence for the visual motion-driven aspect of this behavior mainly exhibited by adult zebrafish. Although there were no significant main effects of age and genotype, we found a significant three-way interaction between contrast level, age, and genotype. In the contrast domain, the changes in optomotor responses and thus in the detection of motion direction were age- and genotype-specific. Accordingly, these behavioral findings suggest a strong but complicated relationship between visual motion characteristics and the cholinergic system during neural aging.en_US
dc.description.provenanceSubmitted by Esma Aytürk (esma.babayigit@bilkent.edu.tr) on 2022-02-23T08:30:47Z No. of bitstreams: 1 The_optomotor_response_of_aging_zebrafish_reveals_a_complex_relationship_between_visual_motion_characteristics_and_cholinergic_system.pdf: 1536387 bytes, checksum: 49e8710eb495a400a6af80583c05b2f1 (MD5)en
dc.description.provenanceMade available in DSpace on 2022-02-23T08:30:47Z (GMT). No. of bitstreams: 1 The_optomotor_response_of_aging_zebrafish_reveals_a_complex_relationship_between_visual_motion_characteristics_and_cholinergic_system.pdf: 1536387 bytes, checksum: 49e8710eb495a400a6af80583c05b2f1 (MD5) Previous issue date: 2020-10-23en
dc.embargo.release2021-10-23
dc.identifier.doi10.1016/j.neurobiolaging.2020.10.018en_US
dc.identifier.eissn1558-1497
dc.identifier.issn0197-4580
dc.identifier.urihttp://hdl.handle.net/11693/77564
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttps://doi.org/10.1016/j.neurobiolaging.2020.10.018en_US
dc.source.titleNeurobiology of Agingen_US
dc.subjectAgingen_US
dc.subjectMotion detectionen_US
dc.subjectDirectionen_US
dc.subjectZebrafishen_US
dc.subjectAcetylcholineen_US
dc.titleThe optomotor response of aging zebrafish reveals a complex relationship between visual motion characteristics and cholinergic systemen_US
dc.typeArticleen_US

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