Functional subdomains within human FFA

Date
2013
Authors
Çukur, T.
Huth, A. G.
Nishimoto, S.
Gallant, J. L.
Advisor
Supervisor
Co-Advisor
Co-Supervisor
Instructor
Source Title
Journal of Neuroscience
Print ISSN
0270-6474
Electronic ISSN
Publisher
Society for Neuroscience
Volume
33
Issue
42
Pages
16748 - 16766
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
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Abstract

The fusiform face area (FFA) is a well-studied human brain region that shows strong activation for faces. In functional MRI studies, FFA is often assumed to be a homogeneous collection of voxels with similar visual tuning. To test this assumption, we used natural movies and a quantitative voxelwise modeling and decoding framework to estimate category tuning profiles for individual voxels within FFA. We find that the responses in most FFA voxels are strongly enhanced by faces, as reported in previous studies. However, we also find that responses of individual voxels are selectively enhanced or suppressed by a wide variety of other categories and that these broader tuning profiles differ across FFA voxels. Cluster analysis of category tuning profiles across voxels reveals three spatially segregated functional subdomains within FFA. These subdomains differ primarily in their responses for nonface categories, such as animals, vehicles, and communication verbs. Furthermore, this segregation does not depend on the statistical threshold used to define FFA from responses to functional localizers. These results suggest that voxels within FFA represent more diverse information about object and action categories than generally assumed. © 2013 the authors.

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Keywords
Adult, Brain Mapping, Female, Functional Neuroimaging, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Occipital Lobe, Pattern Recognition, Visual, Photic Stimulation, Temporal Lobe, Visual Perception
Citation
Published Version (Please cite this version)