Thinking outside the silicon box: molecular and logic as an additional layer of selectivity in singlet oxygen generation for photodynamic therapy

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dc.citation.epage49en_US
dc.citation.issueNumber1en_US
dc.citation.spage48en_US
dc.citation.volumeNumber131en_US
dc.contributor.authorOzlem, S.en_US
dc.contributor.authorAkkaya, E. U.en_US
dc.date.accessioned2016-02-08T10:05:40Z
dc.date.available2016-02-08T10:05:40Z
dc.date.issued2009en_US
dc.departmentDepartment of Chemistryen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractA simple derivative of a well-known dye bodipy appears to be a satisfactory sensitizer for singlet oxygen. Moreover, the rate of singlet oxygen generation can be modulated by two cancer-related cellular parameters, sodium ion concentration and acidity. Singlet oxygen generation rate is maximal when sodium ions and an organic acid were added. The operation of this molecular automaton follows AND logic, which introduces an additional layer of selectivity in the photodynamic action of the reagent. It should also be noted that in this system sensing, computing and actuating functions are realized within a single molecule. Copyright © 2008 American Chemical Society.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:05:40Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2009en
dc.identifier.doi10.1021/ja808389ten_US
dc.identifier.issn0002-7863
dc.identifier.urihttp://hdl.handle.net/11693/22855
dc.language.isoEnglishen_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/ja808389ten_US
dc.source.titleJournal of the American Chemical Societyen_US
dc.subjectCellular parametersen_US
dc.subjectPhotodynamic actionen_US
dc.subjectSingle moleculeen_US
dc.subjectSinglet oxygenen_US
dc.subjectSinglet oxygen generationen_US
dc.subjectSodium ion concentrationen_US
dc.subjectSodium ionsen_US
dc.subjectGas generatorsen_US
dc.subjectMetal ionsen_US
dc.subjectOrganic acidsen_US
dc.subjectPhotodynamic therapyen_US
dc.subjectMolecular oxygenen_US
dc.titleThinking outside the silicon box: molecular and logic as an additional layer of selectivity in singlet oxygen generation for photodynamic therapyen_US
dc.typeArticleen_US

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Department of Chemistry
Institute of Materials Science and Nanotechnology (UNAM)