Mineralized peptide nanofiber gels for enhanced osteogenic differentiation

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buir.contributor.authorGüler, Mustafa O.
dc.citation.epage845en_US
dc.citation.issueNumber8en_US
dc.citation.spage837en_US
dc.citation.volumeNumber4en_US
dc.contributor.authorEren, E. D.en_US
dc.contributor.authorTansik, G.en_US
dc.contributor.authorTekinay, A. B.en_US
dc.contributor.authorGüler, Mustafa O.en_US
dc.date.accessioned2019-02-21T16:01:28Zen_US
dc.date.available2019-02-21T16:01:28Zen_US
dc.date.issued2018en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractMineral deposition is observed in both bacterial and eukaryotic organisms through a broad range of mechanisms. Both organic and inorganic components play crucial roles in the formation of mineralized tissues, and acidic proteins are particularly important in this context owing to their ability to stimulate nucleation of minerals. Here, we present negatively-charged self-assembling peptide amphiphile molecules as a template to nucleate calcium phosphate mineralization in a bioactive scaffold environment. Acidic peptide molecules were shown to induce formation of hydroxyapatite like calcium phosphate mineralization, which was characterized by scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, X-ray diffractometry, oscillatory rheology and atomic force microscopy. The osteoblast-like cells were found to reveal enhanced osteogenic differentiation on pre-mineralized peptide nanofiber networks, suggesting that mineral deposition can be used as a means of enhancing the bioactivity of peptide-based scaffold systems.en_US
dc.embargo.release2019-08-01en_US
dc.identifier.doi10.1002/cnma.201700354en_US
dc.identifier.issn2199-692Xen_US
dc.identifier.urihttp://hdl.handle.net/11693/49851en_US
dc.language.isoEnglishen_US
dc.publisherWileyen_US
dc.relation.isversionofhttps://doi.org/10.1002/cnma.201700354en_US
dc.source.titleChemNanoMaten_US
dc.subjectBiomineralizationen_US
dc.subjectOsteogenic differentiationen_US
dc.subjectPeptides nanofibersen_US
dc.titleMineralized peptide nanofiber gels for enhanced osteogenic differentiationen_US
dc.typeArticleen_US

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Institute of Materials Science and Nanotechnology (UNAM)
Nanotechnology Research Center (NANOTAM)