Polymorphism of spermatocytic seminoma. A morphometric study

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dc.citation.epage203en_US
dc.citation.issueNumber3en_US
dc.citation.spage195en_US
dc.citation.volumeNumber7en_US
dc.contributor.authorFrasik, W.en_US
dc.contributor.authorOkoń, K.en_US
dc.contributor.authorSokołowski, A.en_US
dc.date.accessioned2016-02-08T10:52:52Z
dc.date.available2016-02-08T10:52:52Z
dc.date.issued1994en_US
dc.departmentDepartment of Economicsen_US
dc.description.abstractSpermatocytic seminoma (SS) is one of the testicular tumours. It is distinguished from other germ cell neoplasms by a special type of polymorphism. The aim of the present study was a morphometric analysis (Microplane II image system) of this phenomenon. In histological slides we measured the profile area of nuclei in about 500 adjacent cells. The basic material consisted of 12 cases (c.) of infiltrating SS, and the comparative material included intracanalicular SS (IcSS-1c.), other types of seminoma - typical (TS-2 c.), anaplastic (AS-2c.) and spermatogenesis in an elderly man (Sg-1 c.). We carried out a statistical analysis of the populations of cellular nuclei: we determined nuclear population similarities and differences, as well as their relation to various types of standard distributions such as Erlang, gamma, lognormal, normal and Weibull. Part of the SS histograms including IcSS showed similarities. The mean value of the profile area range from 32.5 to 56.5 μm2. In other types of seminomas this value was much higher. The Kolmogorov-Smirnov two-sample test showed differences between the compared nuclear populations. Lack of the differences was found only between certain SS (including IcSS). The results of comparisons of the populations studied with standard distributions showed that the analysed nuclear populations can be successfully described by more than one theoretical distribution. However, among the spermatocytic seminomas analysed, in contrast to TS and AS, we found distributions not corresponding to any of the standard distributions. The results of our findings argue also against the occurrence of haploid nuclei in SS cells. In slides from SS there were forms much larger than the nuclei of spermatocytes in Sg. In combination with the data concerning ploidy of the neoplasm we postulate that SS nuclear polymorphism is dependent both on maturation and atypia.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:52:52Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 1994en
dc.identifier.eissn2210-7177en_US
dc.identifier.issn0921-8912en_US
dc.identifier.urihttp://hdl.handle.net/11693/25951
dc.language.isoEnglishen_US
dc.publisherHindawi Publishing Corporationen_US
dc.source.titleAnalytical Cellular Pathologyen_US
dc.subjectMorphometryen_US
dc.subjectNuclear polymorphismen_US
dc.subjectSpermatocytic seminomaen_US
dc.subjectCell Differentiationen_US
dc.subjectCell Nucleusen_US
dc.subjectHumanen_US
dc.subjectImage Processing, Computer-Assisteden_US
dc.subjectMaleen_US
dc.subjectSeminomaen_US
dc.subjectTesticular Neoplasmsen_US
dc.titlePolymorphism of spermatocytic seminoma. A morphometric studyen_US
dc.typeArticleen_US

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