Synthesis and characterization of amino acid conjugates of oleanolic acid and their in vitro cytotoxic effect on HCC cell lines

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buir.contributor.authorMustufa, Muhammad Ayaz
buir.contributor.authorÖzen, Çiğdem
buir.contributor.authorÖztürk, Mehmet
dc.citation.epage1496en_US
dc.citation.issueNumber5en_US
dc.citation.spage1491en_US
dc.citation.volumeNumber27en_US
dc.contributor.authorMustufa, Muhammad Ayazen_US
dc.contributor.authorHashmi, I. A.en_US
dc.contributor.authorManzoor, S.en_US
dc.contributor.authorAhmed, A.en_US
dc.contributor.authorAhmed, V.en_US
dc.contributor.authorAslam, A.en_US
dc.contributor.authorÖzen, Çiğdemen_US
dc.contributor.authorNaqvi, N.en_US
dc.contributor.authorÖztürk, Mehmeten_US
dc.contributor.authorAli, F. I.en_US
dc.date.accessioned2016-02-08T10:59:10Z
dc.date.available2016-02-08T10:59:10Z
dc.date.issued2014en_US
dc.departmentGenetics and Biotechnology Research Center (BİLGEN)en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractOleanolic acid (3β-hydroxy-olean-12-en-28-oic acid; OA-01), a pentacyclic triterpene, exhibit a wide range of pharmacological and biological activities. We have isolated oleanolic acid from methanolic extract of Periploca aphylla, collected from surroundings of Karachi in the month of February. Furthermore, four known and two new C-28 amino acid conjugates of oleanolic acid were prepared to explore potential of these compounds on HCCs and one breast cancer cell line. Cytotoxic effects revealed that as compare to parent compound (OA-01), two derivatives OA-04 (p<0.0001) and OA-06 (p<0.01) showed significantly increased/higher inhibition rates.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:59:10Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2014en
dc.identifier.issn1011-601X
dc.identifier.urihttp://hdl.handle.net/11693/26392
dc.language.isoEnglishen_US
dc.publisherPakistan Journal of Pharmaceutical Sciencesen_US
dc.source.titlePakistan Journal of Pharmaceutical Sciencesen_US
dc.subjectOleanolic aciden_US
dc.subjectAmino aciden_US
dc.subjectHCC cell linesen_US
dc.subjectAmidesen_US
dc.subjectPeriploca aphyllaen_US
dc.subjectCell survivalen_US
dc.subjectLiver cell carcinomaen_US
dc.subjectBreast tumoren_US
dc.subjectLiver tumoren_US
dc.titleSynthesis and characterization of amino acid conjugates of oleanolic acid and their in vitro cytotoxic effect on HCC cell linesen_US
dc.typeArticleen_US

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