Local delivery of doxorubicin through supramolecular peptide amphiphile nanofiber gels

buir.contributor.authorGüler, Mustafa O.
dc.citation.epage76en_US
dc.citation.issueNumber1en_US
dc.citation.spage67en_US
dc.citation.volumeNumber5en_US
dc.contributor.authorCinar, G.en_US
dc.contributor.authorOzdemir, A.en_US
dc.contributor.authorHamsici, S.en_US
dc.contributor.authorGunay, G.en_US
dc.contributor.authorDana, A.en_US
dc.contributor.authorTekinay, A. B.en_US
dc.contributor.authorGüler, Mustafa O.en_US
dc.date.accessioned2018-04-12T11:07:27Z
dc.date.available2018-04-12T11:07:27Z
dc.date.issued2017en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractPeptide amphiphiles (PAs) self-assemble into supramolecular nanofiber gels that provide a suitable environment for encapsulation of both hydrophobic and hydrophilic molecules. The PA gels have significant advantages for controlled delivery applications due to their high capacity to retain water, biocompatibility, and biodegradability. In this study, we demonstrate injectable supramolecular PA nanofiber gels for drug delivery applications. Doxorubicin (Dox), as a widely used chemotherapeutic drug for breast cancer treatment, was encapsulated within the PA gels prepared at different concentrations. Physical and chemical properties of the gels were characterized, and slow release of the Dox molecules through the supramolecular PA nanofiber gels was studied. In addition, the diffusion constants of the drug molecules within the PA nanofiber gels were estimated using fluorescence recovery after the photobleaching (FRAP) method. The PA nanofiber gels did not show any cytotoxicity and the encapsulation strategy enhanced the activity of drug molecules on cellular viability through prolonged release compared to direct administration under in vitro conditions. Moreover, the local in vivo injection of the Dox encapsulated PA nanofiber gels (Dox/PA) to the tumor site demonstrated the lowest tumor growth rate compared to the direct Dox injection and increased the apoptotic cells within the tumor tissue for local drug release through the PA nanofiber gels under in vivo conditions.en_US
dc.description.provenanceMade available in DSpace on 2018-04-12T11:07:27Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2017en
dc.identifier.doi10.1039/c6bm00656fen_US
dc.identifier.issn2047-4830
dc.identifier.urihttp://hdl.handle.net/11693/37254
dc.language.isoEnglishen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionofhttps://doi.org/10.1039/c6bm00656fen_US
dc.source.titleBiomaterials Scienceen_US
dc.subjectAmphiphilesen_US
dc.subjectBiocompatibilityen_US
dc.subjectBiodegradabilityen_US
dc.subjectMoleculesen_US
dc.subjectNanofibersen_US
dc.subjectPeptidesen_US
dc.subjectPhotobleachingen_US
dc.subjectPolypeptidesen_US
dc.subjectSupramolecular chemistryen_US
dc.subjectTumorsen_US
dc.subjectBreast cancer treatmenten_US
dc.subjectChemotherapeutic drugsen_US
dc.subjectControlled deliveryen_US
dc.subjectDrug delivery applicationsen_US
dc.subjectFluorescence recoveryen_US
dc.subjectHydrophobic and hydrophilicen_US
dc.subjectPeptide amphiphilesen_US
dc.subjectPhysical and chemical propertiesen_US
dc.subjectGelsen_US
dc.subjectAmphophileen_US
dc.subjectDoxorubicinen_US
dc.subjectNanofiberen_US
dc.subjectPeptideen_US
dc.subjectDoxorubicinen_US
dc.subjectNanofiberen_US
dc.subjectPeptideen_US
dc.subjectSurfactanten_US
dc.subjectAnimal experimenten_US
dc.subjectAnimal modelen_US
dc.subjectAnimal tissueen_US
dc.subjectArticleen_US
dc.subjectBleachingen_US
dc.subjectBreast cancer cell lineen_US
dc.subjectBreast carcinomaen_US
dc.subjectCell viabilityen_US
dc.subjectConcentration (parameters)en_US
dc.subjectControlled studyen_US
dc.subjectCytotoxicityen_US
dc.subjectDrug delivery systemen_US
dc.subjectDrug releaseen_US
dc.subjectFemaleen_US
dc.subjectMouseen_US
dc.subjectNanoencapsulationen_US
dc.subjectNonhumanen_US
dc.subjectPhysical chemistryen_US
dc.subjectPriority journalen_US
dc.subjectBreast tumoren_US
dc.subjectChemical phenomenaen_US
dc.titleLocal delivery of doxorubicin through supramolecular peptide amphiphile nanofiber gelsen_US
dc.typeArticleen_US

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