Red emitting, cucurbituril-capped, pH-responsive conjugated oligomer-based nanoparticles for drug delivery and cellular Imaging

Simple item page
dc.citation.epage3374en_US
dc.citation.issueNumber9en_US
dc.citation.spage3366en_US
dc.citation.volumeNumber15en_US
dc.contributor.authorPennakalathil, J.en_US
dc.contributor.authorJahja, E.en_US
dc.contributor.authorOzdemir, E. S.en_US
dc.contributor.authorKonu, Ö.en_US
dc.contributor.authorTuncel, D.en_US
dc.date.accessioned2015-07-28T12:02:10Z
dc.date.available2015-07-28T12:02:10Z
dc.date.issued2014-07-30en_US
dc.departmentDepartment of Chemistryen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractHere we report the synthesis of nanoparticles based on a conjugated oligomer which is synthesized through Heckcoupling of divinylfluorene and dibromobenzothiodiazole monomers. These water dispersible nanoparticles emit in the region of red tailing to the near-infrared region of the spectrum with high fluorescent quantum yield and brightness. The nanoparticles were found to be stable in water for a prolonged time without forming any aggregates and could carry camptothecin, an anticancer drug with high loading efficiency. MTT cell viability studies performed with breast cancer cell lines showed that halfmaximal inhibitory concentration (IC50) values of nanoparticles for MCF7 and MDA-MB-231 were 44.7 μM and 24.8 μM, respectively. In order to further decrease the cytotoxicity and increase the stability of nanoparticles, amine groups were disguised by capping with cucurbit[7]uril (CB7). Drug release studies showed that drugs were released at low pH (at 5.0) faster than physiological pH (7.4) confirming the pH-responsive nature of the nanoparticles. On the other hand, CB7-capped drug-loaded nanoparticles regulated the release rate by providing slower release at pH 7.4 than the nanoparticles in the absence of CB7s. IC50 values for camptothecin in the presence of nanoparticles with or without CB7 were significantly reduced in MCF7 and MDAMB-231 cells.en_US
dc.description.provenanceMade available in DSpace on 2015-07-28T12:02:10Z (GMT). No. of bitstreams: 1 8130.pdf: 5763274 bytes, checksum: f66ef788aee954120c996222a91756a1 (MD5)en
dc.identifier.doi10.1021/bm500839jen_US
dc.identifier.eissn1526-4602
dc.identifier.issn1525-7797
dc.identifier.urihttp://hdl.handle.net/11693/12607
dc.language.isoEnglishen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/bm500839jen_US
dc.source.titleBiomacromoleculesen_US
dc.titleRed emitting, cucurbituril-capped, pH-responsive conjugated oligomer-based nanoparticles for drug delivery and cellular Imagingen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
8130.pdf
Size:
5.5 MB
Format:
Adobe Portable Document Format
Description:
Full printable version
Download

Collections

Scholarly Publications - Chemistry
Scholarly Publications - Molecular Biology and Genetics
Scholarly Publications - NANOTAM
Scholarly Publications - UNAM