Activatable photosensitizers: agents for selective photodynamic therapy

Date
2017
Advisor
Supervisor
Co-Advisor
Co-Supervisor
Instructor
Source Title
Advanced Functional Materials
Print ISSN
1616-301X
Electronic ISSN
1616-3028
Publisher
Wiley-VCH Verlag
Volume
27
Issue
5
Pages
1604053 - 1 - 1604053 - 11
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Series
Abstract

Recent developments in the design of bifunctional and activatable photosensitizers rejuvenate the aging field of photodynamic sensitization and photodynamic therapy. While systematic studies have uncovered new dyes that can serve as potential photosensitizers, the most promising results have come from studies aimed at gaining precise control over the location and rate of cytotoxic singlet oxygen generation. As a consequence, higher selectivities and efficiencies in photodynamic treatment protocols are now within reach. This feature article highlights the variety of approaches that have been pursued to improve photodynamic therapy and to transform simple photosensitizers into smarter theranostic agents.

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Book Title
Keywords
Gas generators, Imaging techniques, Photochemical reactions, Photodynamic therapy, Bi-functional, Cytotoxic, Photodynamic treatments, Precise control, Singlet oxygen, Singlet oxygen generation, Systematic study, Theranostic agents, Photosensitizers
Citation
Published Version (Please cite this version)