Antibacterial electrospun nanofibers from triclosan/cyclodextrin inclusion complexes

Date
2014
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Source Title
Colloids and Surfaces B: Biointerfaces
Print ISSN
0927-7765
Electronic ISSN
Publisher
Elsevier
Volume
116
Issue
Pages
612 - 619
Language
English
Type
Article
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Abstract

The electrospinning of nanofibers (NF) from cyclodextrin inclusion complexes (CD-IC) with an antibacterial agent (triclosan) was achieved without using any carrier polymeric matrix. Polymer-free triclosan/CD-IC NF were electrospun from highly concentrated (160% CD, w/w) aqueous triclosan/CD-IC suspension by using two types of chemically modified CD; hydroxypropyl-beta-cyclodextrin (HPβCD) and hydroxypropyl-gamma-cyclodextrin (HPγCD). The morphological characterization of the electrospun triclosan/CD-IC NF by SEM elucidated that the triclosan/HPβCD-IC NF and triclosan/HPγCD-IC NF were bead-free having average fiber diameter of 520±250nm and 1100±660nm, respectively. The presence of triclosan and the formation of triclosan/CD-IC within the fiber structure were confirmed by 1H-NMR, FTIR, XRD, DSC, and TGA studies. The initial 1:1molar ratio of the triclosan:CD was kept for triclosan/HPβCD-IC NF after the electrospinning and whereas 0.7:1molar ratio was observed for triclosan/HPγCD-IC NF and some uncomplexed triclosan was detected suggesting that the complexation efficiency of triclosan with HPγCD was lower than that of HPβCD. The antibacterial properties of triclosan/CD-IC NF were tested against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. It was observed that triclosan/HPβCD-IC NF and triclosan/HPγCD-IC NF showed better antibacterial activity against both bacteria compared to uncomplexed pure triclosan.

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Keywords
Antibacterial activity, Cyclodextrin, Electrospinning, Inclusion complex, Nanofibers, Triclosan, Bacteria, Cyclodextrins, Electrospinning, Escherichia coli, Suspensions (fluids), Anti-bacterial activity, Antibacterial properties, Average fiber diameters, Cyclodextrin inclusion complexes, Electrospun nanofibers, Inclusion complex, Morphological characterization, Triclosan, Nanofibers, 2 hydroxypropyl beta cyclodextrin, Cyclodextrin, Hydroxypropyl gamma cyclodextrin, Nanofiber, Triclosan, Triclosan hydroxypropyl beta cyclodextrin, Triclosan hydroxypropyl gamma cyclodextrin, Unclassified drug, Antiinfective agent, Cyclodextrin, Nanofiber, Triclosan, Absorption, Antibacterial activity, Article, Chemical composition, Chemical structure, Comparative study, Concentration (parameters), Conductance, Electrospinning, Escherichia coli, Fiber diameter, Morphology, Nonhuman, Physical parameters, Priority journal, Staphylococcus aureus, Surface property, viscosity, Chemistry, Drug effects, Electric conductivity, Electrode, Microbial sensitivity test, Particle size, Synthesis, Escherichia coli, Negibacteria, Posibacteria, Staphylococcus aureus, Anti-Bacterial Agents, Cyclodextrins, Electric Conductivity, Electrodes, Escherichia coli, Microbial Sensitivity Tests, Molecular Structure, Nanofibers, Particle Size, Staphylococcus aureus, Surface Properties, Triclosan, Viscosity
Citation
Published Version (Please cite this version)