In situ synthesis and dynamic simulation of molecularly imprinted polymeric nanoparticles on a micro-reactor system

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buir.contributor.authorErdem, Özgecan
buir.contributor.authorEş, İsmail
buir.contributor.authorAtabay, Maryam
buir.contributor.authorGüngen, Murat Alp
buir.contributor.authorÖlmez, Kadriye
buir.contributor.authorİnci, Fatih
buir.contributor.orcidÖlmez, Kadriye|0000-0002-5381-7968
buir.contributor.orcidİnci, Fatih|0000-0002-9918-5038
dc.citation.epage4840-16en_US
dc.citation.issueNumber1
dc.citation.spage4840-1
dc.citation.volumeNumber14
dc.contributor.authorErdem, Özgecan
dc.contributor.authorEş, Ismail
dc.contributor.authorSaylan, Y.
dc.contributor.authorAtabay, Maryam
dc.contributor.authorGüngen, Murat Alp
dc.contributor.authorÖlmez, Kadriye
dc.contributor.authorDenizli, A.
dc.contributor.authorİnci, Fatih
dc.date.accessioned2024-03-21T15:43:16Z
dc.date.available2024-03-21T15:43:16Z
dc.date.issued2023-08-10
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)
dc.description.abstractCurrent practices in synthesizing molecularly imprinted polymers face challenges—lengthy process, low-productivity, the need for expensive and sophisticated equipment, and they cannot be controlled in situ synthesis. Herein, we present a micro-reactor for in situ and continuously synthesizing trillions of molecularly imprinted polymeric nanoparticles that contain molecular fingerprints of bovine serum albumin in a short period of time (5-30 min). Initially, we performed COMSOL simulation to analyze mixing efficiency with altering flow rates, and experimentally validated the platform for synthesizing nanoparticles with sizes ranging from 52-106 nm. Molecular interactions between monomers and protein were also examined by molecular docking and dynamics simulations. Afterwards, we benchmarked the micro-reactor parameters through dispersity and concentration of molecularly imprinted polymers using principal component analysis. Sensing assets of molecularly imprinted polymers were examined on a metamaterial sensor, resulting in 81% of precision with high selectivity (4.5 times), and three cycles of consecutive use. Overall, our micro-reactor stood out for its high productivity (48-288 times improvement in assay-time and 2 times improvement in reagent volume), enabling to produce 1.4-1.5 times more MIPs at one-single step, and continuous production compared to conventional strategy. © 2023, Springer Nature Limited.
dc.description.provenanceMade available in DSpace on 2024-03-21T15:43:16Z (GMT). No. of bitstreams: 1 In_situ_synthesis_and_dynamic_simulation_of_molecularly_imprinted_polymeric_nanoparticles_on_a_microreactor_systemNature_Communications.pdf: 3912972 bytes, checksum: 62a8d31f3a7db36b13c6b1951fab9ef0 (MD5) Previous issue date: 2023-08-10en
dc.identifier.doi10.1038/s41467-023-40413-8
dc.identifier.eissn2041-1723
dc.identifier.urihttps://hdl.handle.net/11693/115053
dc.language.isoen_US
dc.publisherNature Research
dc.relation.isversionofhttps://dx.doi.org/10.1038/s41467-023-40413-8
dc.rightsCC BY 4.0 DEED (Attribution 4.0 International)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.source.titleNature Communications
dc.titleIn situ synthesis and dynamic simulation of molecularly imprinted polymeric nanoparticles on a micro-reactor system
dc.typeArticle

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