Thymol/cyclodextrin inclusion complex nanofibrous webs: enhanced water solubility, high thermal stability and antioxidant property of thymol

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buir.contributor.authorÇelebioğlu, Aslı
buir.contributor.authorYıldız, Zehra İrem
buir.contributor.authorUyar, Tamer
buir.contributor.orcidUyar, Tamer|0000-0002-3989-4481
dc.citation.epage290en_US
dc.citation.spage280en_US
dc.citation.volumeNumber106en_US
dc.contributor.authorÇelebioğlu, Aslıen_US
dc.contributor.authorYıldız, Zehra İremen_US
dc.contributor.authorUyar, Tameren_US
dc.date.accessioned2019-02-21T16:01:34Zen_US
dc.date.available2019-02-21T16:01:34Zen_US
dc.date.issued2018en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractThe development of novel nanomaterials that provide an efficient encapsulation and protection for the active food additives is one of the main focuses of current research efforts at food application areas. From this point of view, in this study, nanofibrous webs from inclusion complexes (IC) of modified cyclodextrins (hydroxypropyl-β-cyclodextrin (HPβCD), hydroxypropyl-γ-cyclodextrin (HPγCD) and methyl-β-cyclodextrin (MβCD)) and essential oils compound (i.e. thymol) was produced through electrospinning technique. While pure thymol has a highly volatile nature, the volatility of thymol was effectively suppressed by the inclusion complexation and ~ 88-100% (w/w) of thymol was preserved in electrospun thymol/cyclodextrin inclusion complex nanofibers (Thymol/CD-IC NF). The aqueous solubility enhancement for hydrophobic thymol was demonstrated by phase solubility diagram which also suggested the 1:1 M inclusion complexation between thymol and CD molecules. Besides, Thymol/CD-IC NF displayed quite fast disintegration in water compared to poorly water soluble thymol. By inclusion complexation, high temperature stability for volatile thymol was achieved for Thymol/CD-IC NF samples. The loading of thymol in Thymol/CD-IC NF conferred DPPH radical scavenging ability to these nanofibrous webs. So, the Thymol/CD-IC NF have shown antioxidant activity along with enhanced water solubility and high thermal stability of thymol. In brief, encapsulation of essential oil compounds such as thymol in electrospun CD-IC nanofibers can promote its potential application in food and oral-care products by associating the large surface area of nanofibrous webs along with CD inclusion complexation which provides enhanced water solubility and antioxidant property, and high temperature stability for thymol.en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey 498 (TUBITAK)-Turkey (Project # 213M185 ).en_US
dc.embargo.release2019-04-01en_US
dc.identifier.doi10.1016/j.foodres.2017.12.062en_US
dc.identifier.eissn1873-7145en_US
dc.identifier.issn0963-9969en_US
dc.identifier.urihttp://hdl.handle.net/11693/49875en_US
dc.language.isoEnglishen_US
dc.publisherPergamon Pressen_US
dc.relation.isversionofhttps://doi.org/10.1016/j.foodres.2017.12.062en_US
dc.relation.project213M185 - Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITAK - 498 - 213M185en_US
dc.source.titleFood Research Internationalen_US
dc.subjectAntioxidant propertyen_US
dc.subjectCyclodextrinen_US
dc.subjectElectrospinningen_US
dc.subjectInclusion complexen_US
dc.subjectNanofibersen_US
dc.subjectTemperature stabilityen_US
dc.subjectThymolen_US
dc.subjectWater-solubilityen_US
dc.titleThymol/cyclodextrin inclusion complex nanofibrous webs: enhanced water solubility, high thermal stability and antioxidant property of thymolen_US
dc.typeArticleen_US

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Institute of Materials Science and Nanotechnology (UNAM)
Nanotechnology Research Center (NANOTAM)